-transparent.png){kind=logo}
Elastoviscosometric parameters of DNA from normal subjects of different age and patients with Down syndrome were assessed. Characteristics of DNA isolated from lymphocytes trisomic for chromosome 21 were studied to compare normal and pathological rates of ageing. Increased elastoviscosity was observed in normal subjects above 60. Similar changes in this parameter were noted in aberrant lymphocytes isolated from patients above 10. The established dependence of elastoviscosity on ethidium bromide concentration led to the assumption that an increase in hydrodynamic DNA volume in human leukocytes during ageing was due to accumulation of spontaneous irreparable DNA lesions.
Related Publications
S E Bresler, and
E F Davidenkova, and
K K Gurgenidze, and
L A Noskin, and
E I Shvarts
July 1986,
Molecular & general genetics : MGG,
S E Bresler, and
E F Davidenkova, and
K K Gurgenidze, and
L A Noskin, and
E I Shvarts
August 1978,
Journal of cellular physiology,
S E Bresler, and
E F Davidenkova, and
K K Gurgenidze, and
L A Noskin, and
E I Shvarts
February 1996,
Investigative ophthalmology & visual science,
S E Bresler, and
E F Davidenkova, and
K K Gurgenidze, and
L A Noskin, and
E I Shvarts
January 1999,
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,
S E Bresler, and
E F Davidenkova, and
K K Gurgenidze, and
L A Noskin, and
E I Shvarts
March 2011,
PloS one,
S E Bresler, and
E F Davidenkova, and
K K Gurgenidze, and
L A Noskin, and
E I Shvarts
September 2007,
Journal of materials science. Materials in medicine,
S E Bresler, and
E F Davidenkova, and
K K Gurgenidze, and
L A Noskin, and
E I Shvarts
April 1993,
American journal of human genetics,
S E Bresler, and
E F Davidenkova, and
K K Gurgenidze, and
L A Noskin, and
E I Shvarts
December 1992,
Biochimica et biophysica acta,
S E Bresler, and
E F Davidenkova, and
K K Gurgenidze, and
L A Noskin, and
E I Shvarts
December 1981,
Mechanisms of ageing and development,
S E Bresler, and
E F Davidenkova, and
K K Gurgenidze, and
L A Noskin, and
E I Shvarts
January 1982,
Experimental gerontology,
