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Experimental and human data in young volunteers suggest that tuberoinfundibular dopaminergic systems physiologically inhibit pituitary secretion of beta-endorphin. This hypothesis was verified in patients with Parkinson's disease, a human model of a selective deficit of dopamine. Both previously untreated patients and patients who had been without chronic treatment for 1 week showed plasma beta-endorphin levels significantly higher than those of healthy age-matched controls. Plasma beta-lipotropin levels of patients and of controls were similar. There was no correlation between plasma opioid levels and age, severity, or duration of the disease. In five patients retested during chronic treatment, plasma levels both of beta-endorphin and of beta-lipotropin significantly decreased. This decrease approximately paralleled clinical improvement. The finding that in Parkinson's disease there is a reversible disinhibition of pituitary secretion of beta-endorphin confirms that this secretion is physiologically inhibited by tuberoinfundibular dopaminergic systems.
M Franceschi, and
R Cecchetto, and
A E Panerai, and
G Truci, and
S Smirne, and
N Canal
April 1987,
European journal of obstetrics, gynecology, and reproductive biology,
M Franceschi, and
R Cecchetto, and
A E Panerai, and
G Truci, and
S Smirne, and
N Canal
January 1982,
Journal of neural transmission,
M Franceschi, and
R Cecchetto, and
A E Panerai, and
G Truci, and
S Smirne, and
N Canal
January 1986,
Nephron,
M Franceschi, and
R Cecchetto, and
A E Panerai, and
G Truci, and
S Smirne, and
N Canal
November 1992,
Psychoneuroendocrinology,
M Franceschi, and
R Cecchetto, and
A E Panerai, and
G Truci, and
S Smirne, and
N Canal
March 1982,
Masui. The Japanese journal of anesthesiology,
M Franceschi, and
R Cecchetto, and
A E Panerai, and
G Truci, and
S Smirne, and
N Canal
August 1988,
Cardiologia (Rome, Italy),
M Franceschi, and
R Cecchetto, and
A E Panerai, and
G Truci, and
S Smirne, and
N Canal
September 1983,
The Tohoku journal of experimental medicine,
M Franceschi, and
R Cecchetto, and
A E Panerai, and
G Truci, and
S Smirne, and
N Canal
June 1985,
Experimental and clinical endocrinology,
M Franceschi, and
R Cecchetto, and
A E Panerai, and
G Truci, and
S Smirne, and
N Canal
January 1990,
Acta cardiologica,
M Franceschi, and
R Cecchetto, and
A E Panerai, and
G Truci, and
S Smirne, and
N Canal
December 1984,
Life sciences,
