3D printed microneedles for insulin skin delivery. 2018

Cristiane Patricia Pissinato Pere, and Sophia N Economidou, and Gurprit Lall, and Clémentine Ziraud, and Joshua S Boateng, and Bruce D Alexander, and Dimitrios A Lamprou, and Dennis Douroumis
Medway School of Pharmacy, University of Kent, Medway Campus, Central Avenue, Chatham Maritime, Chatham, Kent ME4 4TB, United Kingdom.

In this study, polymeric microneedle patches were fabricated by stereolithography, a 3D printing technique, for the transdermal delivery of insulin. A biocompatible resin was photopolymerized to build pyramid and cone microneedle designs followed by inkjet print coating of insulin formulations. Trehalose, mannitol and xylitol were used as drug carriers with the aim to preserve insulin integrity and stability but also to facilitate rapid release rates. Circular dichroism and Raman analysis demonstrated that all carriers maintained the native form of insulin, with xylitol presenting the best performance. Franz cell release studies were used for in vitro determination of insulin release rates in porcine skin. Insulin was released rapidly within 30 min irrespectively of the microneedle design. 3D printing was proved an effective technology for the fabrication of biocompatible and scalable microneedle patches.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D009339 Needles Sharp instruments used for puncturing or suturing. Hypodermic Needles,Hypodermic Needle,Needle,Needle, Hypodermic,Needles, Hypodermic
D000279 Administration, Cutaneous The application of suitable drug dosage forms to the skin for either local or systemic effects. Cutaneous Drug Administration,Dermal Drug Administration,Drug Administration, Dermal,Percutaneous Administration,Skin Drug Administration,Transcutaneous Administration,Transdermal Administration,Administration, Dermal,Administration, Transcutaneous,Administration, Transdermal,Cutaneous Administration,Cutaneous Administration, Drug,Dermal Administration,Drug Administration, Cutaneous,Skin Administration, Drug,Administration, Cutaneous Drug,Administration, Dermal Drug,Administration, Percutaneous,Administrations, Cutaneous,Administrations, Cutaneous Drug,Administrations, Dermal,Administrations, Dermal Drug,Administrations, Percutaneous,Administrations, Transcutaneous,Administrations, Transdermal,Cutaneous Administrations,Cutaneous Administrations, Drug,Cutaneous Drug Administrations,Dermal Administrations,Dermal Drug Administrations,Drug Administrations, Cutaneous,Drug Administrations, Dermal,Drug Skin Administrations,Percutaneous Administrations,Skin Administrations, Drug,Skin Drug Administrations,Transcutaneous Administrations,Transdermal Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012867 Skin The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D013678 Technology, Pharmaceutical The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients. Technology, Pharmacy,Pharmaceutic Technology,Pharmaceutical Technology,Pharmacy Technology,Technology, Pharmaceutic
D016503 Drug Delivery Systems Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity. Drug Targeting,Delivery System, Drug,Delivery Systems, Drug,Drug Delivery System,Drug Targetings,System, Drug Delivery,Systems, Drug Delivery,Targeting, Drug,Targetings, Drug
D057968 Transdermal Patch A medicated adhesive patch placed on the skin to deliver a specific dose of medication into the bloodstream. Patch, Transdermal,Patchs, Transdermal,Transdermal Patchs
D023421 Models, Animal Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing. Experimental Animal Models,Laboratory Animal Models,Animal Model,Animal Model, Experimental,Animal Model, Laboratory,Animal Models,Animal Models, Experimental,Animal Models, Laboratory,Experimental Animal Model,Laboratory Animal Model,Model, Animal,Model, Experimental Animal,Model, Laboratory Animal,Models, Experimental Animal,Models, Laboratory Animal

Related Publications

Cristiane Patricia Pissinato Pere, and Sophia N Economidou, and Gurprit Lall, and Clémentine Ziraud, and Joshua S Boateng, and Bruce D Alexander, and Dimitrios A Lamprou, and Dennis Douroumis
April 2018, Lab on a chip,
Cristiane Patricia Pissinato Pere, and Sophia N Economidou, and Gurprit Lall, and Clémentine Ziraud, and Joshua S Boateng, and Bruce D Alexander, and Dimitrios A Lamprou, and Dennis Douroumis
January 2021, International journal of pharmaceutics,
Cristiane Patricia Pissinato Pere, and Sophia N Economidou, and Gurprit Lall, and Clémentine Ziraud, and Joshua S Boateng, and Bruce D Alexander, and Dimitrios A Lamprou, and Dennis Douroumis
May 2024, Advanced healthcare materials,
Cristiane Patricia Pissinato Pere, and Sophia N Economidou, and Gurprit Lall, and Clémentine Ziraud, and Joshua S Boateng, and Bruce D Alexander, and Dimitrios A Lamprou, and Dennis Douroumis
March 2021, International journal of pharmaceutics,
Cristiane Patricia Pissinato Pere, and Sophia N Economidou, and Gurprit Lall, and Clémentine Ziraud, and Joshua S Boateng, and Bruce D Alexander, and Dimitrios A Lamprou, and Dennis Douroumis
August 2021, International journal of pharmaceutics,
Cristiane Patricia Pissinato Pere, and Sophia N Economidou, and Gurprit Lall, and Clémentine Ziraud, and Joshua S Boateng, and Bruce D Alexander, and Dimitrios A Lamprou, and Dennis Douroumis
January 2021, iScience,
Cristiane Patricia Pissinato Pere, and Sophia N Economidou, and Gurprit Lall, and Clémentine Ziraud, and Joshua S Boateng, and Bruce D Alexander, and Dimitrios A Lamprou, and Dennis Douroumis
July 2022, Micromachines,
Cristiane Patricia Pissinato Pere, and Sophia N Economidou, and Gurprit Lall, and Clémentine Ziraud, and Joshua S Boateng, and Bruce D Alexander, and Dimitrios A Lamprou, and Dennis Douroumis
July 2018, Bioengineering (Basel, Switzerland),
Cristiane Patricia Pissinato Pere, and Sophia N Economidou, and Gurprit Lall, and Clémentine Ziraud, and Joshua S Boateng, and Bruce D Alexander, and Dimitrios A Lamprou, and Dennis Douroumis
September 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences,
Cristiane Patricia Pissinato Pere, and Sophia N Economidou, and Gurprit Lall, and Clémentine Ziraud, and Joshua S Boateng, and Bruce D Alexander, and Dimitrios A Lamprou, and Dennis Douroumis
August 2023, ACS biomaterials science & engineering,
Copied contents to your clipboard!