The effects of vitamins A, B complex, E, and ADE on the eosinophilia, body weight, number of obtained larvae and distribution of larvae of Trichinella pseudospiralis were examined in mice. The increased eosinophilia started to appear in the majority of infected mice from day 7 p.i., the maximum being around day 21 p.i. The highest values of eosinophilia were observed in the mice after application of vitamin B complex. In spite of considerable individual differences, the greatest decrease in body weight occurred in mice receiving vitamins E and B complex. The greatest numbers of larvae were obtained from mice receiving vitamins E and B complex, which is proportional to the increase in eosinophilia. The numbers of muscle larvae in untreated mice and in those receiving vitamins ADE were approximately the same. The lowest numbers of larvae occurred in mice receiving vitamin A. In all mice groups the greatest numbers of larvae were localized in the left foreleg and diaphragm.