Biomaterial Database

The endorphin response of women to sleep loss and exercise. 1988

R G McMurray, and J F Fafrowicz, and M Berry

Exercise Physiology Laboratory, University of North Carolina, Chapel Hill, 27514.

The purpose of this investigation was to examine the combined effect of sleep loss and exercise on plasma beta-endorphin levels. Seven healthy women completed a 1-h run at approximately 80% VO2 max on a motorized treadmill after a normal night's sleep and again after 36 h of sleep deprivation. Venous blood samples were obtained before and immediately after each run. Oxygen uptake, heart rate, blood pressure, and ratings of perceived exertion were obtained during each trial. Resting beta-endorphin levels were 4.5 +/- 0.2 pmol.L-1 for the control trial and 4.7 +/- 0.7 pmol.L-1 for the sleep deprived trials. Exercise after normal sleep resulted in an average endorphin level of 19.4 +/- 6.8 pmol.L-1. Sleep loss did not significantly alter the post-exercise beta-endorphin response, averaging 19.4 +/- 8.7 pmol.L-1. Both trials resulted in similar oxygen uptake (41.8 +/- 2.3 ml.kg-1.min-1), heart rate (163 +/- 4 beats.min-1), mean blood pressure (98 +/- 3 mm Hg), and rating of perceived exertion (12.0 +/- 0.2). These results suggest that 36 h of sleep deprivation does not impose sufficient stress to alter the resting endorphin response, nor does it affect the endorphin response to high-intensity exercise.

UI	MeSH Term	Description	Entries
D010101	Oxygen Consumption	The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)	Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D005082	Physical Exertion	Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.	Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D005260	Female		Females
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D001615	beta-Endorphin	A 31-amino acid peptide that is the C-terminal fragment of BETA-LIPOTROPIN. It acts on OPIOID RECEPTORS and is an analgesic. Its first four amino acids at the N-terminal are identical to the tetrapeptide sequence of METHIONINE ENKEPHALIN and LEUCINE ENKEPHALIN.	Endorphin, beta,beta-Endorphin (1-31),beta Endorphin
D012892	Sleep Deprivation	The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.	Inadequate Sleep,Insufficient Sleep,Insufficient Sleep Syndrome,REM Sleep Deprivation,Sleep Debt,Sleep Fragmentation,Sleep Insufficiency,Deprivation, REM Sleep,Deprivation, Sleep,Fragmentation, Sleep,Insufficiencies, Sleep,Insufficiency, Sleep,Insufficient Sleep Syndromes,Sleep Deprivation, REM,Sleep Insufficiencies,Sleep, Inadequate,Sleep, Insufficient,Syndrome, Insufficient Sleep