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OBJECTIVE to identify the relationship between the magnitude of neovascularization of an atherosclerotic plaque and its other processes, such as atheromatosis, macrophage responses, hemorrhages, and calcification. METHODS 48 carotid atherosclerotic plaques all their way underwent morphopathological examination, by assessing the magnitude of neovascularization (total vessel density per plague cm2; density of vessels of different diameters; localization in section), atheromatosis (a volume fraction), foam cells (a score of 0 to 5), hemorrhages (a score of 0 to 4), and calcification (a score of 0 to 4). The Mann-Whitney U test and the Spearman correlation coefficient with p<0.05 were used in the statistical analysis. RESULTS There was a substantial variability in vessel diameters and densities in the plaque with a drastic predominance of vessels smaller than 20 µm in diameter (69.8±14.3%). The vessels with a diameter as large as 20 µm were more frequently located in the area of accumulation of foam cells or organizing hemorrhages (p<0.03), unlike those with a diameter of more than 40 µm, which were more common in the areas of connective tissue, especially adjacent to large calcifications, and in the foci of organized hemorrhages (p<0.008). Intensified calcification was accompanied by the higher density of vessels having a diameter of more than 40 µm (p<0.038) and particularly of those with a diameter of more than 60 µm (p=0.006). The degree of hemorrhages and the number of foam cells were unrelated to the density of vessels, but these increased with their localization in the surface areas of a plaque (p=0.000342). With the increasing severity of atheromatosis, there was a decrease in the density of vessels larger than 20 µm in diameter (p=0.00042). CONCLUSIONS The number, diameter, and location of vessels in the plaque serve as a dynamic reflection of its destructive and reparative processes; and a larger number of vessels having a diameter of more than 40 µm can be an indicator for the activation of reparative processes.
A N Evdokimenko, and
P L Anufriev, and
K N Kulichenkova, and
T S Gulevskaya, and
M M Tanashyan
January 2008,
Journal of clinical ultrasound : JCU,
A N Evdokimenko, and
P L Anufriev, and
K N Kulichenkova, and
T S Gulevskaya, and
M M Tanashyan
November 2014,
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition,
A N Evdokimenko, and
P L Anufriev, and
K N Kulichenkova, and
T S Gulevskaya, and
M M Tanashyan
March 2012,
Bulletin of experimental biology and medicine,
A N Evdokimenko, and
P L Anufriev, and
K N Kulichenkova, and
T S Gulevskaya, and
M M Tanashyan
October 2014,
Stroke,
A N Evdokimenko, and
P L Anufriev, and
K N Kulichenkova, and
T S Gulevskaya, and
M M Tanashyan
December 2019,
International angiology : a journal of the International Union of Angiology,
A N Evdokimenko, and
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K N Kulichenkova, and
T S Gulevskaya, and
M M Tanashyan
June 1999,
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A N Evdokimenko, and
P L Anufriev, and
K N Kulichenkova, and
T S Gulevskaya, and
M M Tanashyan
January 2018,
Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery,
A N Evdokimenko, and
P L Anufriev, and
K N Kulichenkova, and
T S Gulevskaya, and
M M Tanashyan
December 2004,
Stroke,
A N Evdokimenko, and
P L Anufriev, and
K N Kulichenkova, and
T S Gulevskaya, and
M M Tanashyan
November 1999,
American heart journal,
A N Evdokimenko, and
P L Anufriev, and
K N Kulichenkova, and
T S Gulevskaya, and
M M Tanashyan
July 2003,
IEEE transactions on medical imaging,
