Biomaterial Database

[Advances in Zika vaccines]. 2017

Ran Wang, and Hui Chen, and Jing An

Aedes (a genus of mosquitoes) transfers Zika virus (ZIKV) to humans. About two billion people worldwide live in ZIKV-affected areas. The outbreak of ZIKV in Central and South America threats public health worldwide, especially for pregnant women and their fetuses. ZIKV infection has become one of the major causes of neonatal congenital microcephaly and adult Guillain-Barre syndrome. No effective vaccine and treatment are available now against ZIKV infection. The first Zika vaccine is a DNA vaccine which affords complete protection against ZIKV and induces a high level of specific antibody titers. Advantages of DNA vaccines are simple to design and produce, safe for adults and fetuses, and without virulence recovery induced by reproducible vaccines. Some positive vaccines including traditional and emerging ones are in research and some progresses have been achieved. This article reviews the current situation and progress of Zika vaccines.

UI	MeSH Term	Description	Entries
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000071243	Zika Virus Infection	A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	Congenital Zika Syndrome,Congenital Zika Virus Infection,Fever, Zika,ZikV Infection,Zika Fever,Zika Virus Disease,Disease, Zika Virus,Infection, ZikV,Infection, Zika Virus,Virus Disease, Zika,Virus Infection, Zika
D000071244	Zika Virus	An arbovirus in the FLAVIVIRUS genus of the family FLAVIVIRIDAE. Originally isolated in the Zika Forest of UGANDA it has been introduced to Asia and the Americas.	Virus, Zika,ZikV
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014765	Viral Vaccines	Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.	Viral Vaccine,Vaccine, Viral,Vaccines, Viral
D014774	Virulence	The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.	Pathogenicity