Experimental urography with new non-ionic dimeric and monomeric contrast agents. 1987

E Holtz, and K Golman
Department of Pharmacology and Toxicology, Nycomed As, Oslo, Norway.

The potential usefulness in urography of two new non-ionic dimeric ratio 6 contrast media (iodixanol and cpd. 2-5410-4A) and a new non-ionic monomeric ratio 3 contrast medium, iopentol, was investigated in a rabbit model and compared with iohexol. Urinary iodine concentrations, urine flow, estimated attenuation capacity and radiographic scoring by visual observation was determined at three dose levels in normally hydrated and at one dose level in dehydrated animals. At the high dose (500 mg I/kg) and in dehydrated animals at 200 mg I/kg the dimers yielded higher urinary iodine concentrations, an increased estimated attenuation capacity and a higher radiographic score than the monomers. Iopentol was as effective as iohexol in all the recorded parameters.

UI MeSH Term Description Entries
D007472 Iohexol An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. Compound 545,Exypaque,Iohexol 350,Nycodenz,Omnipaque
D008297 Male Males
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D003287 Contrast Media Substances used to allow enhanced visualization of tissues. Radiopaque Media,Contrast Agent,Contrast Agents,Contrast Material,Contrast Materials,Radiocontrast Agent,Radiocontrast Agents,Radiocontrast Media,Agent, Contrast,Agent, Radiocontrast,Agents, Contrast,Agents, Radiocontrast,Material, Contrast,Materials, Contrast,Media, Contrast,Media, Radiocontrast,Media, Radiopaque
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014283 Triiodobenzoic Acids Triiodo-substituted derivatives of BENZOIC ACID. Triiodobenzoic Acid,Acid, Triiodobenzoic,Acids, Triiodobenzoic
D014567 Urography Radiography of any part of the URINARY TRACT. Pyelography,Pyelogram,Urogram,Pyelograms,Pyelographies,Urograms,Urographies

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