BIOMAT Database Logo BIOMAT Database Logo

Effects of contrast media on aortic endothelium. Experiments in the rat with non-ionic monomeric and monoacidic dimeric contrast media. 1980

U Nyman, and T Almén

Injury to the aortic endothelium in rats was evaluated under a light microscope by a silver staining method after application of ionic monomeric (diatrizoate and metrizoate), non-ionic monomeric (C29 with different pH and buffers, 593, iohexol and metrizamide) and monoacidic dimeric (ioxaglate) contrast media, and iso- and hypertonic solutions of sodium chloride. In iodine equivalent concentrations the ionic monomers were significantly more toxic than the other contrast media. No significant was found between the non-ionic monomers, monoacidic dimer and sodium chloride solutions equiosmolal to the ionic monomers. Isotonic saline was the least harmful solution.

UI MeSH Term Description Entries
D007463 Iodobenzoates Benzoic acid esters or salts substituted with one or more iodine atoms. Iodobenzoic Acids,Acids, Iodobenzoic
D007472 Iohexol An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. Compound 545,Exypaque,Iohexol 350,Nycodenz,Omnipaque
D007479 Iopamidol A non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures. B-15,000,B-15000,Gastromiro,Iopamidol, (+-)-Isomer,Iopamidol, (R)-Isomer,Iopamidol, Sodium Salt, (S)-Isomer,Iopamiro,Isovue,Isovue 370,Jopamidol,Niopam,SQ 13,396,Solutrast,Solutrast 370,Solutrast Gastro,B 15,000,B 15000,B15,000,B15000
D007483 Iothalamic Acid A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts. Iotalamic Acid,Methalamic Acid,Angio-Conray,Conray 420,Iodothalamate,Iothalamate,Iothalamic Acid, Calcium (2:1) Salt,Iothalamic Acid, Monosilver (1+) Salt,Iothalamic Acid, Monosodium Salt,Iothalamic Acid, Monosodium Salt, Dimer,Lopamidol,Sodium Iothalamate,Acid, Iotalamic,Acid, Iothalamic,Acid, Methalamic,Angio Conray,AngioConray,Iothalamate, Sodium
D007485 Ioxaglic Acid A low-osmolar, ionic contrast medium used in various radiographic procedures. Ioxaglate,Ioxaglate Meglumine,Ioxaglate Sodium,Hexabrix,Ioxaglic Acid Monosodium Salt,Ioxaglic Acid, Calcium Salt (2:1),Methylglucamine Ioxaglate,P-286 (Contrast Media),P286 (Contrast Media),Ioxaglate, Methylglucamine,Meglumine, Ioxaglate
D008297 Male Males
D008536 Meglumine 1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium. Methylglucamine
D008793 Metrizamide A solute for density gradient centrifugation offering higher maximum solution density without the problems of increased viscosity. It is also used as a resorbable, non-ionic contrast medium. Amipak,Amipaque
D008794 Metrizoic Acid A diagnostic radiopaque that usually occurs as the sodium salt. Metrizoate,Benzoic acid, 3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodo-,Isopaque,Metrizoate Sodium,Triosil
D009994 Osmolar Concentration The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent. Ionic Strength,Osmolality,Osmolarity,Concentration, Osmolar,Concentrations, Osmolar,Ionic Strengths,Osmolalities,Osmolar Concentrations,Osmolarities,Strength, Ionic,Strengths, Ionic

Related Publications

U Nyman, and T Almén
Proteinuria following nephroangiography. VII. Comparison between ionic monomeric, monoacidic dimeric and non-ionic contrast media in the dog.
January 1980, Acta radiologica. Supplementum,
U Nyman, and T Almén
Cardiovascular effects of ionic monomeric, ionic dimeric and non-ionic contrast media. Effects in animals on myocardial contractile force, pulmonary and aortic blood pressure and aortic endothelium.
January 1975, Investigative radiology,
U Nyman, and T Almén
Contrast media and regional renal blood flow. A study of the effects of ionic and non-ionic monomeric and dimeric contrast media in the rat.
January 1992, Acta radiologica. Supplementum,
U Nyman, and T Almén
Comparison of excretory urographic contrast effects of dimeric and monomeric non-ionic iodinated contrast media in dogs.
July 2007, The Journal of veterinary medical science,
U Nyman, and T Almén
Effects of non-ionic monomeric and dimeric iodinated contrast media on renal and systemic haemodynamics in rats.
January 2000, Fundamental & clinical pharmacology,
U Nyman, and T Almén
[Non-ionic iodinated dimeric versus monomeric X-ray contrast media: effects on complement factors in vivo].
March 2006, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin,
U Nyman, and T Almén
Experimental urography with new non-ionic dimeric and monomeric contrast agents.
January 1987, Acta radiologica. Supplementum,
U Nyman, and T Almén
Allergies correlated to adverse reactions induced by non-ionic monomeric and ionic dimeric contrast media for contrast enhanced CT examination.
September 2002, Nihon Hoshasen Gijutsu Gakkai zasshi,
U Nyman, and T Almén
Frequency of late allergy-like adverse reactions following injection of intravascular non-ionic contrast media. A retrospective study comparing a non-ionic monomeric contrast medium with a non-ionic dimeric contrast medium.
May 1998, Acta radiologica (Stockholm, Sweden : 1987),
U Nyman, and T Almén
Effects of intravenous administration of a new nonionic dimeric contrast medium on the coronary circulation. Comparison with monomeric ionic and nonionic media.
October 1985, Investigative radiology,
Copied contents to your clipboard!