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This study assessed the effects of phentolamine on rewarming patterns and metabolic acidosis in 37 patients subjected to hypothermia during cardiopulmonary bypass for the performance of aortocoronary bypass grafting. An additional 16 patients undergoing the same surgery received no phentolamine and served as a control group. In all patients, sodium bicarbonate (44.6 mEq) was administered only when the negative base excess was 3.0 mEq/L or greater. Sixty-eight percent of the patients receiving phentolamine and 56% of the control patients exhibited a uniform rewarming pattern in which the rectal, hand, and foot temperatures increased in parallel. In 32% of the patients receiving phentolamine and in 44% of the control patients, rectal and hand temperatures increased more than foot temperature during rewarming. Analysis of base excess values in the subgroups of patients with similar rewarming patterns indicated that base deficits were significantly decreased in patients receiving phentolamine. Phentolamine administration was also associated with significantly lower blood lactate levels and sodium bicarbonate requirements, as well as improvements in overall appearance and mental status. These data suggest that the routine use of phentolamine in patients undergoing cardiopulmonary bypass may be associated with more uniform body cooling and rewarming and improved tissue perfusion.
K G Bridges, and
G A Reichard, and
H MacVaugh, and
J R Kues, and
W H Cevallos, and
M J Lechman, and
W S Hoffman, and
J S Donahoo
August 1987,
Journal of cardiothoracic anesthesia,
K G Bridges, and
G A Reichard, and
H MacVaugh, and
J R Kues, and
W H Cevallos, and
M J Lechman, and
W S Hoffman, and
J S Donahoo
July 1958,
Surgery,
K G Bridges, and
G A Reichard, and
H MacVaugh, and
J R Kues, and
W H Cevallos, and
M J Lechman, and
W S Hoffman, and
J S Donahoo
January 1981,
Arzneimittel-Forschung,
K G Bridges, and
G A Reichard, and
H MacVaugh, and
J R Kues, and
W H Cevallos, and
M J Lechman, and
W S Hoffman, and
J S Donahoo
December 1997,
Critical care medicine,
K G Bridges, and
G A Reichard, and
H MacVaugh, and
J R Kues, and
W H Cevallos, and
M J Lechman, and
W S Hoffman, and
J S Donahoo
July 1986,
Anesthesia and analgesia,
K G Bridges, and
G A Reichard, and
H MacVaugh, and
J R Kues, and
W H Cevallos, and
M J Lechman, and
W S Hoffman, and
J S Donahoo
August 1966,
The Journal of surgical research,
K G Bridges, and
G A Reichard, and
H MacVaugh, and
J R Kues, and
W H Cevallos, and
M J Lechman, and
W S Hoffman, and
J S Donahoo
December 1990,
Masui. The Japanese journal of anesthesiology,
K G Bridges, and
G A Reichard, and
H MacVaugh, and
J R Kues, and
W H Cevallos, and
M J Lechman, and
W S Hoffman, and
J S Donahoo
November 2000,
Anesthesiology,
K G Bridges, and
G A Reichard, and
H MacVaugh, and
J R Kues, and
W H Cevallos, and
M J Lechman, and
W S Hoffman, and
J S Donahoo
November 2001,
The Journal of thoracic and cardiovascular surgery,
K G Bridges, and
G A Reichard, and
H MacVaugh, and
J R Kues, and
W H Cevallos, and
M J Lechman, and
W S Hoffman, and
J S Donahoo
April 1961,
Annals of surgery,
