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Control of hypertension during cardiopulmonary bypass with urapidil and phentolamine. 1981

E Göb, and A Barankay, and J A Richter

The vasodilating effect of 6-(3-[4-(o-methoxy-phenyl)-piperazin-1-yl]-propylamino)-1,3-dimethyluracil (urapidil, Ebrantil) and phentolamine was investigated during extracorporeal circulation in patients undergoing coronary artery bypass (CABG) operations. To compare the vasodilating effect, 10 patients received 2 times 25 mg urapidil, and another 10 patients 2 times 5 mg phentolamine when mean arterial blood pressure (MAP) exceeded 100 mgHg. Both drugs caused a significant (p less than 0.01) decrease in mean arterial blood pressure and total peripheral resistance (TPR), using constant flow (Qecc). Central venous pressure (CVP), measured in the inferior vena cava, showed no significant change, while a marked volume loss (delta V) in the oxygenator was observed. There was no significant difference in the measured cardiovascular parameters in the two groups of patients. The peripheral vasodilating effect of urapidil, expressed in mg was found 5 times weaker than that of phentolamine. Urapidil was found effective in the treatment of hypertension during extracorporeal circulation.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D007430 Intraoperative Care Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests. Care, Intraoperative
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010646 Phentolamine A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease. Fentolamin,Phentolamine Mesilate,Phentolamine Mesylate,Phentolamine Methanesulfonate,Phentolamine Mono-hydrochloride,Regitine,Regityn,Rogitine,Z-Max,Mesilate, Phentolamine,Mesylate, Phentolamine,Methanesulfonate, Phentolamine,Mono-hydrochloride, Phentolamine,Phentolamine Mono hydrochloride
D010879 Piperazines Compounds that are derived from PIPERAZINE.
D002315 Cardiopulmonary Bypass Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs. Heart-Lung Bypass,Bypass, Cardiopulmonary,Bypass, Heart-Lung,Bypasses, Cardiopulmonary,Bypasses, Heart-Lung,Cardiopulmonary Bypasses,Heart Lung Bypass,Heart-Lung Bypasses
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

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