Ameliorative effect of carvacrol against propiconazole-induced neurobehavioral toxicity in rats. 2018

Peter A Noshy, and Mohamed A Elhady, and Abdel Azeim A Khalaf, and Mervat M Kamel, and Eman I Hassanen
Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt. Electronic address: Vet_peter@cu.edu.eg.

Propiconazole (PCZ) is a triazole fungicide extensively used in agriculture. Carvacrol (CAR) is a naturally occurring phenolic monoterpene which has various biological and pharmacological effects. The present study was designed to investigate the neurobehavioral toxic effects of PCZ in albino rats and to evaluate the ameliorative role of CAR against such toxic effects. Sixty adult male rats were used in this investigation; they were randomly and equally divided into 4 groups: control group, PCZ group, CAR group and PCZ + CAR group. PCZ (75 mg/kg) and/or CAR (50 mg/kg) were administered daily by oral gavage for 8 weeks. Behavioral investigation clearly demonstrated the negative impact of PCZ on psychological, motor and cognitive brain functions. Exposure to PCZ also adversely affected the measured oxidative stress and lipid peroxidation parameters in brain tissue. A significant decrease in activity of acetylcholinesterase enzyme in neural tissue was also observed in PCZ-exposed rats. Histopathological examination of the cerebrum, cerebellum, and hippocampus showed various histopathological lesions after exposure to PCZ which were confirmed by immunohistochemical examination. On the other hand, co-administration of CAR ameliorated most of the undesirable effects of PCZ.

UI MeSH Term Description Entries
D008297 Male Males
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D000081007 Cymenes A subclass of monoterpenes that contain a single benzene ring structure with an isopropyl group and one or more methyl groups. Benzenoid Menthane,Benzenoid Menthanes,Cymene,Menthane, Benzenoid,Menthanes, Benzenoid
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014230 Triazoles Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3. Triazole
D015227 Lipid Peroxidation Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor. Lipid Peroxidations,Peroxidation, Lipid,Peroxidations, Lipid
D016896 Treatment Outcome Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series. Rehabilitation Outcome,Treatment Effectiveness,Clinical Effectiveness,Clinical Efficacy,Patient-Relevant Outcome,Treatment Efficacy,Effectiveness, Clinical,Effectiveness, Treatment,Efficacy, Clinical,Efficacy, Treatment,Outcome, Patient-Relevant,Outcome, Rehabilitation,Outcome, Treatment,Outcomes, Patient-Relevant,Patient Relevant Outcome,Patient-Relevant Outcomes
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D018384 Oxidative Stress A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi). Anti-oxidative Stress,Antioxidative Stress,DNA Oxidative Damage,Nitro-Oxidative Stress,Oxidative Cleavage,Oxidative DNA Damage,Oxidative Damage,Oxidative Injury,Oxidative Nitrative Stress,Oxidative Stress Injury,Oxidative and Nitrosative Stress,Stress, Oxidative,Anti oxidative Stress,Anti-oxidative Stresses,Antioxidative Stresses,Cleavage, Oxidative,DNA Damage, Oxidative,DNA Oxidative Damages,Damage, DNA Oxidative,Damage, Oxidative,Damage, Oxidative DNA,Injury, Oxidative,Injury, Oxidative Stress,Nitrative Stress, Oxidative,Nitro Oxidative Stress,Nitro-Oxidative Stresses,Oxidative Cleavages,Oxidative DNA Damages,Oxidative Damage, DNA,Oxidative Damages,Oxidative Injuries,Oxidative Nitrative Stresses,Oxidative Stress Injuries,Oxidative Stresses,Stress Injury, Oxidative,Stress, Anti-oxidative,Stress, Antioxidative,Stress, Nitro-Oxidative,Stress, Oxidative Nitrative,Stresses, Nitro-Oxidative

Related Publications

Peter A Noshy, and Mohamed A Elhady, and Abdel Azeim A Khalaf, and Mervat M Kamel, and Eman I Hassanen
June 2023, Journal of biochemical and molecular toxicology,
Peter A Noshy, and Mohamed A Elhady, and Abdel Azeim A Khalaf, and Mervat M Kamel, and Eman I Hassanen
January 2016, Pharmaceutical biology,
Peter A Noshy, and Mohamed A Elhady, and Abdel Azeim A Khalaf, and Mervat M Kamel, and Eman I Hassanen
October 2016, Journal of biochemical and molecular toxicology,
Peter A Noshy, and Mohamed A Elhady, and Abdel Azeim A Khalaf, and Mervat M Kamel, and Eman I Hassanen
January 2021, Neurotoxicology and teratology,
Peter A Noshy, and Mohamed A Elhady, and Abdel Azeim A Khalaf, and Mervat M Kamel, and Eman I Hassanen
November 2019, Environmental science and pollution research international,
Peter A Noshy, and Mohamed A Elhady, and Abdel Azeim A Khalaf, and Mervat M Kamel, and Eman I Hassanen
January 2014, Acta chirurgica Belgica,
Peter A Noshy, and Mohamed A Elhady, and Abdel Azeim A Khalaf, and Mervat M Kamel, and Eman I Hassanen
January 2014, International journal of clinical and experimental medicine,
Peter A Noshy, and Mohamed A Elhady, and Abdel Azeim A Khalaf, and Mervat M Kamel, and Eman I Hassanen
February 2015, Pharmaceutical biology,
Peter A Noshy, and Mohamed A Elhady, and Abdel Azeim A Khalaf, and Mervat M Kamel, and Eman I Hassanen
May 2012, Environmental toxicology and pharmacology,
Peter A Noshy, and Mohamed A Elhady, and Abdel Azeim A Khalaf, and Mervat M Kamel, and Eman I Hassanen
January 2019, International journal of nanomedicine,
Copied contents to your clipboard!