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Treatment of K562 cells, a human erythroleukemia cell line, with desferrioxamine raised the levels of the receptor for transferrin (Tf) two- to threefold over that of the control cells. The levels of receptor were reduced by at least 50 and 35% of that of the control in cells treated with diferric Tf and ferric ammonium citrate, respectively. These changes were of total cellular receptors with no alteration in the proportion of receptors found on the cell surface. The half-lives of the receptor were identical in cells treated with desferrioxamine, diferric Tf, or ferric ammonium citrate. Cells metabolically labeled with [35S]methionine showed a 2.5-fold increase in the rate of receptor synthesis when treated with desferrioxamine and a 35 and 65% decrease when treated with ferric ammonium citrate and diferric Tf, respectively. In vitro translations of polyadenylated mRNA isolated from cells incubated with desferrioxamine showed a 2.5-fold increase in translatable mRNA for the receptor, whereas treatment of cells with ferric ammonium citrate and diferric Tf resulted in a 25 and 50% reduction, respectively, in translatable mRNA for this receptor.
K K Rao, and
D Shapiro, and
E Mattia, and
K Bridges, and
R Klausner
November 1984,
The Journal of biological chemistry,
K K Rao, and
D Shapiro, and
E Mattia, and
K Bridges, and
R Klausner
May 1995,
Blood,
K K Rao, and
D Shapiro, and
E Mattia, and
K Bridges, and
R Klausner
December 1990,
The Biochemical journal,
K K Rao, and
D Shapiro, and
E Mattia, and
K Bridges, and
R Klausner
January 1984,
Progress in clinical and biological research,
K K Rao, and
D Shapiro, and
E Mattia, and
K Bridges, and
R Klausner
April 1983,
The Journal of biological chemistry,
K K Rao, and
D Shapiro, and
E Mattia, and
K Bridges, and
R Klausner
October 2017,
Metallomics : integrated biometal science,
K K Rao, and
D Shapiro, and
E Mattia, and
K Bridges, and
R Klausner
January 2006,
Blood cells, molecules & diseases,
K K Rao, and
D Shapiro, and
E Mattia, and
K Bridges, and
R Klausner
January 1993,
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine,
K K Rao, and
D Shapiro, and
E Mattia, and
K Bridges, and
R Klausner
April 1993,
European journal of biochemistry,
K K Rao, and
D Shapiro, and
E Mattia, and
K Bridges, and
R Klausner
June 1994,
Molecular and cellular biochemistry,
