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Fecal mutagenic activity and dietary pattern of rural and urban Finnish population groups with distinct risk for the development of colon cancer were studied in a low-risk population in rural Kuopio and an intermediate-risk population in urban Helsinki. The average daily intake of protein and fat was the same in the two groups but the frequency of consumption of whole-grain cereals and whole-grain bread, as well as the amount of fiber from the bread were higher in Kuopio as compared to Helsinki. Fecal samples collected for 2 days were incubated under anaerobic conditions at 37 degrees C for 96 h, extracted with hexane: peroxide-free diethyl ether, partially purified on a silica Sep-Pak cartridge, and assayed for mutagenic activity using the Salmonella typhimurium/mammalian microsome system. The fecal mutagenic activity was observed with the tester strains TA98 and TA100 with and without microsomal activation in both the population groups. The percentage of samples showing fecal mutagenic ratio greater than 3 with TA98 and TA100 with microsomal activation, was higher in volunteers from Helsinki than in Kuopio.
B S Reddy, and
C Sharma, and
L Mathews, and
A Engle, and
K Laakso, and
K Choi, and
P Puska, and
R Korpella
August 1989,
Cancer research,
B S Reddy, and
C Sharma, and
L Mathews, and
A Engle, and
K Laakso, and
K Choi, and
P Puska, and
R Korpella
December 1976,
The American journal of clinical nutrition,
B S Reddy, and
C Sharma, and
L Mathews, and
A Engle, and
K Laakso, and
K Choi, and
P Puska, and
R Korpella
March 1982,
Cancer research,
B S Reddy, and
C Sharma, and
L Mathews, and
A Engle, and
K Laakso, and
K Choi, and
P Puska, and
R Korpella
January 1983,
Nutrition and cancer,
B S Reddy, and
C Sharma, and
L Mathews, and
A Engle, and
K Laakso, and
K Choi, and
P Puska, and
R Korpella
June 1977,
Cancer,
B S Reddy, and
C Sharma, and
L Mathews, and
A Engle, and
K Laakso, and
K Choi, and
P Puska, and
R Korpella
January 2003,
Water science and technology : a journal of the International Association on Water Pollution Research,
B S Reddy, and
C Sharma, and
L Mathews, and
A Engle, and
K Laakso, and
K Choi, and
P Puska, and
R Korpella
January 2021,
International journal of environmental research and public health,
B S Reddy, and
C Sharma, and
L Mathews, and
A Engle, and
K Laakso, and
K Choi, and
P Puska, and
R Korpella
January 2010,
Acta neurochirurgica. Supplement,
B S Reddy, and
C Sharma, and
L Mathews, and
A Engle, and
K Laakso, and
K Choi, and
P Puska, and
R Korpella
January 1990,
Advances in experimental medicine and biology,
B S Reddy, and
C Sharma, and
L Mathews, and
A Engle, and
K Laakso, and
K Choi, and
P Puska, and
R Korpella
February 2006,
Metabolism: clinical and experimental,
