-transparent.png){kind=logo}
The analysis of the 100 000 X g supernatant fraction of cultured rat glomerular mesangial cells with DEAE-cellulose ion-exchange chromatography revealed a large peak showing the activity of a protein kinase (protein kinase C) which depended on phospholipid and diolein as well as Ca2+. Furthermore, it was shown that angiotensin II (AII) (10(-6)M) induced rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate, leading to production of diacylglycerol rich in arachidonic acid, in the cultured rat mesangial cells. These results suggest that activation of protein kinase C resulting from enhancement of phosphoinositide metabolism may be important as an intracellular regulatory mechanism of AII upon cultured mesangial cells.
Y Orita, and
Y Fujiwara, and
S Ochi, and
Y Tanaka, and
T Kamada
January 1983,
Methods in enzymology,
Y Orita, and
Y Fujiwara, and
S Ochi, and
Y Tanaka, and
T Kamada
June 1985,
The American journal of physiology,
Y Orita, and
Y Fujiwara, and
S Ochi, and
Y Tanaka, and
T Kamada
October 1984,
The Journal of investigative dermatology,
Y Orita, and
Y Fujiwara, and
S Ochi, and
Y Tanaka, and
T Kamada
February 1986,
Biochemical and biophysical research communications,
Y Orita, and
Y Fujiwara, and
S Ochi, and
Y Tanaka, and
T Kamada
August 1983,
Biochemical and biophysical research communications,
Y Orita, and
Y Fujiwara, and
S Ochi, and
Y Tanaka, and
T Kamada
August 1995,
FEBS letters,
Y Orita, and
Y Fujiwara, and
S Ochi, and
Y Tanaka, and
T Kamada
December 1986,
Cellular immunology,
Y Orita, and
Y Fujiwara, and
S Ochi, and
Y Tanaka, and
T Kamada
December 1990,
Revista espanola de fisiologia,
Y Orita, and
Y Fujiwara, and
S Ochi, and
Y Tanaka, and
T Kamada
September 1986,
Archives of biochemistry and biophysics,
Y Orita, and
Y Fujiwara, and
S Ochi, and
Y Tanaka, and
T Kamada
December 1986,
Molecular and cellular endocrinology,
