The pre-treatment of landfill leachate prior to its co-treatment in the municipal plants of waste water processing could represent an appropriate and cost-effective solution for its management. Pre-treatment is necessary especially to remove heavy metals, which may be transferred to the excess sludge preventing its valorisation. In the present paper, we propose a chemical-physical pre-treatment of leachate using four different granular reactive media able to selectively remove the contaminants present in the leachate. The efficiency of these materials was investigated using synthetic leachate through batch tests and a column test. In the latter case the four materials were placed in two columns connected in series and fed an under constant upward flow (0.5 mL/min). The first column was filled half (50 cm) with a granular mixture of zero valent iron (ZVI) and pumice and half (50 cm) with a granular mixture of ZVI and granular activated carbon (GAC). The second column, which was fed with the effluent of the first column, was filled half with zeolite (chabazite) and half with GAC. Heavy metals were mainly removed by the ZVI/pumice and ZVI/GAC steps with a removal efficiency that was higher than 98, 94 and 90% for copper, nickel and zinc, respectively, after 70 days of operation. Ammonium was removed by zeolite with a removal efficiency of 99% up to 23 days. The average reduction of the chemical oxygen demand (COD) was of 40% for 85 days, whereas chloride and sulphate removal was negligible.