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The state of T-cell receptor beta-chain gene rearrangement in human T-cell leukaemias has been analysed. All forms of leukaemia tested (T-CLL, ALL, PLL, Sezary syndrome and ATL) exhibit rearrangements of C beta genes confirming the clonality of these neoplasias. However we find no evidence for common gene rearrangements nor for restricted rearrangement patterns within this type of neoplasia. We find evidence of T-cells with C beta 1 and C beta 2 rearrangements, sometimes associated with Igh JH rearrangements, but several cases of T-cell leukaemia with a marker inversion of chromosome 14 (q11;q32) do not have Igh JH rearrangements. The results suggest that TCR beta gene rearrangement occurs early in T-cell ontogeny but that this rearrangement is most often irrelevant to leukaemogenesis.
T H Rabbitts, and
A Stinson, and
A Forster, and
L Foroni, and
L Luzzatto, and
D Catovsky, and
L Hammarström, and
C I Smith, and
D Jones, and
A Karpas
December 1986,
Molecular immunology,
T H Rabbitts, and
A Stinson, and
A Forster, and
L Foroni, and
L Luzzatto, and
D Catovsky, and
L Hammarström, and
C I Smith, and
D Jones, and
A Karpas
July 1985,
Lancet (London, England),
T H Rabbitts, and
A Stinson, and
A Forster, and
L Foroni, and
L Luzzatto, and
D Catovsky, and
L Hammarström, and
C I Smith, and
D Jones, and
A Karpas
November 1993,
Archives of dermatology,
T H Rabbitts, and
A Stinson, and
A Forster, and
L Foroni, and
L Luzzatto, and
D Catovsky, and
L Hammarström, and
C I Smith, and
D Jones, and
A Karpas
April 1990,
International journal of cancer,
T H Rabbitts, and
A Stinson, and
A Forster, and
L Foroni, and
L Luzzatto, and
D Catovsky, and
L Hammarström, and
C I Smith, and
D Jones, and
A Karpas
August 1985,
The New England journal of medicine,
T H Rabbitts, and
A Stinson, and
A Forster, and
L Foroni, and
L Luzzatto, and
D Catovsky, and
L Hammarström, and
C I Smith, and
D Jones, and
A Karpas
September 1986,
Journal of immunology (Baltimore, Md. : 1950),
T H Rabbitts, and
A Stinson, and
A Forster, and
L Foroni, and
L Luzzatto, and
D Catovsky, and
L Hammarström, and
C I Smith, and
D Jones, and
A Karpas
February 1994,
European journal of clinical investigation,
T H Rabbitts, and
A Stinson, and
A Forster, and
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D Catovsky, and
L Hammarström, and
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D Jones, and
A Karpas
November 1986,
Japanese journal of cancer research : Gann,
T H Rabbitts, and
A Stinson, and
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D Catovsky, and
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June 1986,
Human pathology,
T H Rabbitts, and
A Stinson, and
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D Jones, and
A Karpas
March 1991,
Cancer research,
