BIOMAT Database Logo BIOMAT Database Logo

ACTH secretory responsiveness of pituitary adrenotroph cell tumor to adrenocorticotropin-releasing factor in Cushing's disease and Nelson's syndrome. 1986

R Takeda, and T Ito, and M Kawato, and H Nakabayashi, and I Miyamori, and T Morise, and H Koshida, and M Ikeda

ACTH-secretory responsiveness of the adrenotroph cell tumors to the exogenous CRF was evaluated in 4 cases of Cushing's disease and 3 cases of Nelson's syndrome. Significantly exaggerated ACTH release was evoked by the intravenous injection of CRF in all 3 cases of Nelson's syndrome, but in Cushing's disease there seemed to be an individual difference in the sensitivity of the pituitary to CRF, probably depending on the functional activity of hypothalamo-pituitary axis.

UI MeSH Term Description Entries
D007030 Hypothalamo-Hypophyseal System A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS. Hypothalamic Hypophyseal System,Hypothalamo-Pituitary-Adrenal Axis,Hypophyseal Portal System,Hypothalamic-Pituitary Unit,Hypothalamic Hypophyseal Systems,Hypothalamic Pituitary Unit,Hypothalamo Hypophyseal System,Hypothalamo Pituitary Adrenal Axis,Portal System, Hypophyseal
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009347 Nelson Syndrome A syndrome characterized by HYPERPIGMENTATION, enlarging pituitary mass, visual defects secondary to compression of the OPTIC CHIASM, and elevated serum ACTH. It is caused by the expansion of an underlying ACTH-SECRETING PITUITARY ADENOMA that grows in the absence of feedback inhibition by adrenal CORTICOSTEROIDS, usually after ADRENALECTOMY.
D010911 Pituitary Neoplasms Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA. Pituitary Cancer,Cancer of Pituitary,Cancer of the Pituitary,Pituitary Adenoma,Pituitary Carcinoma,Pituitary Tumors,Adenoma, Pituitary,Adenomas, Pituitary,Cancer, Pituitary,Cancers, Pituitary,Carcinoma, Pituitary,Carcinomas, Pituitary,Neoplasm, Pituitary,Neoplasms, Pituitary,Pituitary Adenomas,Pituitary Cancers,Pituitary Carcinomas,Pituitary Neoplasm,Pituitary Tumor,Tumor, Pituitary,Tumors, Pituitary
D003346 Corticotropin-Releasing Hormone A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS. ACTH-Releasing Hormone,CRF-41,Corticotropin-Releasing Factor,Corticotropin-Releasing Hormone-41,ACTH-Releasing Factor,CRF (ACTH),Corticoliberin,Corticotropin-Releasing Factor-41,ACTH Releasing Factor,ACTH Releasing Hormone,Corticotropin Releasing Factor,Corticotropin Releasing Factor 41,Corticotropin Releasing Hormone,Corticotropin Releasing Hormone 41
D003480 Cushing Syndrome A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent. Cushing's Syndrome,Hypercortisolism,Syndrome, Cushing,Syndrome, Cushing's
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

R Takeda, and T Ito, and M Kawato, and H Nakabayashi, and I Miyamori, and T Morise, and H Koshida, and M Ikeda
Thyrotropin-releasing hormone stimulation of adrenocorticotropin production by mouse pituitary tumor cells in culture: possible model for anomalous release of adrenocorticotropin by thyrotropin-releasing hormone in some patients with Cushing's disease and Nelson's syndrome.
June 1980, The Journal of clinical investigation,
R Takeda, and T Ito, and M Kawato, and H Nakabayashi, and I Miyamori, and T Morise, and H Koshida, and M Ikeda
Pituitary adenomas that caused Cushing's disease or Nelson's syndrome are not responsive to ovine corticotropin-releasing factor in vitro.
February 1983, The Journal of clinical endocrinology and metabolism,
R Takeda, and T Ito, and M Kawato, and H Nakabayashi, and I Miyamori, and T Morise, and H Koshida, and M Ikeda
Cushing's syndrome with a large pituitary adenoma producing both corticotropin-releasing hormone (CRH) and adrenocorticotropin (ACTH).
July 2002, Internal medicine (Tokyo, Japan),
R Takeda, and T Ito, and M Kawato, and H Nakabayashi, and I Miyamori, and T Morise, and H Koshida, and M Ikeda
Development of Nelson's syndrome in a patient with recurrent Cushing's disease. Analysis of secretory behavior of the pituitary tumor.
February 1988, The American journal of medicine,
R Takeda, and T Ito, and M Kawato, and H Nakabayashi, and I Miyamori, and T Morise, and H Koshida, and M Ikeda
Responsiveness of the hypophyseal-adrenocortical axis to corticotropin-releasing factor in pituitary-dependent Cushing's disease.
September 1983, The Journal of clinical endocrinology and metabolism,
R Takeda, and T Ito, and M Kawato, and H Nakabayashi, and I Miyamori, and T Morise, and H Koshida, and M Ikeda
Cushing's disease and Nelson's syndrome.
January 1980, Clinical neurosurgery,
R Takeda, and T Ito, and M Kawato, and H Nakabayashi, and I Miyamori, and T Morise, and H Koshida, and M Ikeda
Profound amplification of secretory-burst mass and anomalous regularity of ACTH secretory process in patients with Nelson's syndrome compared with Cushing's disease.
June 2004, Clinical endocrinology,
R Takeda, and T Ito, and M Kawato, and H Nakabayashi, and I Miyamori, and T Morise, and H Koshida, and M Ikeda
Profound amplification of secretory-burst mass and anomalous regularity of ACTH secretory process in patients with Nelson's syndrome compared with Cushing's disease.
August 2005, Clinical endocrinology,
R Takeda, and T Ito, and M Kawato, and H Nakabayashi, and I Miyamori, and T Morise, and H Koshida, and M Ikeda
Cushing's disease due to an ACTH-secreting pharyngeal pituitary tumor.
February 2001, European journal of endocrinology,
R Takeda, and T Ito, and M Kawato, and H Nakabayashi, and I Miyamori, and T Morise, and H Koshida, and M Ikeda
The effect of ovine corticotrophin releasing factor (oCRF), bromocriptine and TRH on the secretion of ACTH and alpha-MSH in Nelson's syndrome and Cushing's disease.
July 1986, Clinical endocrinology,
Copied contents to your clipboard!