-transparent.png){kind=logo}
The response of pituitary adenomas obtained surgically from patients with Cushing's disease of Nelson's syndrome to synthetic ovine corticotropin-releasing factor (CRF), vasopressins, somatostatin-28, dexamethasone, 3-isobutylmethylxanthine or high [K+] was examined in vitro by measuring the amount of pro-opiomelanocortin (POMC)-derived peptides secreted into the culture medium. CRF did not stimulate the secretion of adrenocorticotropin-, beta-endorphin-, or gamma 3-melanotropin-like peptides from the pituitary adenomas at concentrations ranging from 1 x 10(-13) M to 1 x 10(-7) M whereas vasopressins, 3-isobutyrl-methylxanthine and high [K+] increased, while somatostatin-28 and dexamethasone suppressed, the secretion of these POMC-derived peptides. These findings suggest that either the pituitary ACTH-producing tumors have lost their receptors to CRF or their post-receptor mechanism to CRF is not functional.
T Shibasaki, and
M Nakahara, and
K Shizume, and
Y Kiyosawa, and
T Suda, and
H Demura, and
A Kuwayama, and
N Kageyama, and
R Benoit, and
N Ling
November 1982,
The Journal of clinical endocrinology and metabolism,
T Shibasaki, and
M Nakahara, and
K Shizume, and
Y Kiyosawa, and
T Suda, and
H Demura, and
A Kuwayama, and
N Kageyama, and
R Benoit, and
N Ling
January 1971,
Progress in atomic medicine,
T Shibasaki, and
M Nakahara, and
K Shizume, and
Y Kiyosawa, and
T Suda, and
H Demura, and
A Kuwayama, and
N Kageyama, and
R Benoit, and
N Ling
June 1986,
Experimental and clinical endocrinology,
T Shibasaki, and
M Nakahara, and
K Shizume, and
Y Kiyosawa, and
T Suda, and
H Demura, and
A Kuwayama, and
N Kageyama, and
R Benoit, and
N Ling
September 1992,
American journal of diseases of children (1960),
T Shibasaki, and
M Nakahara, and
K Shizume, and
Y Kiyosawa, and
T Suda, and
H Demura, and
A Kuwayama, and
N Kageyama, and
R Benoit, and
N Ling
September 1983,
The Journal of clinical endocrinology and metabolism,
T Shibasaki, and
M Nakahara, and
K Shizume, and
Y Kiyosawa, and
T Suda, and
H Demura, and
A Kuwayama, and
N Kageyama, and
R Benoit, and
N Ling
March 1985,
The Journal of clinical endocrinology and metabolism,
T Shibasaki, and
M Nakahara, and
K Shizume, and
Y Kiyosawa, and
T Suda, and
H Demura, and
A Kuwayama, and
N Kageyama, and
R Benoit, and
N Ling
November 1990,
Endocrinology,
T Shibasaki, and
M Nakahara, and
K Shizume, and
Y Kiyosawa, and
T Suda, and
H Demura, and
A Kuwayama, and
N Kageyama, and
R Benoit, and
N Ling
March 1993,
The Journal of pathology,
T Shibasaki, and
M Nakahara, and
K Shizume, and
Y Kiyosawa, and
T Suda, and
H Demura, and
A Kuwayama, and
N Kageyama, and
R Benoit, and
N Ling
December 1990,
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology,
T Shibasaki, and
M Nakahara, and
K Shizume, and
Y Kiyosawa, and
T Suda, and
H Demura, and
A Kuwayama, and
N Kageyama, and
R Benoit, and
N Ling
January 1980,
Clinical neurosurgery,
