Biomaterial Database

Transition of Psychotropic Drugs in Japanese Pharmacopoeia (JP) (Part 17) Transitions in the Standards and Test Methods of Valproic Acid and Sodium Valproate in Japanese Pharmacopoeia (JP), Pharmacopoeia of the USA (USP), British Pharmacopoeia (BP), and the Knowledge and Judgment about Japanese Valeriana, and Valproic Acid from Valeric Acid 2016

Kiyohisa Yanagisawa

Valproic acid (VPA) and sodium valproate (VPA-Na) are used for the treatment of various things today, such as epilepsy and manic-depressive states. Moreover, use has expanded to a variety of applications, such as the prevention of migraine headaches. As a result, a high demand has been maintained. The chemical structure is a branching low-grade saturated fatty acid, which is simpler than other psychotropic drugs. VPA is called 2-propyl-pentanoic acid and 2-propyl-valeric acid under the IUPAC system, and is derived from Valeric acid. This time, the author researched transitions in the standards and testing methods for VPA and VPA-Na in JP, USP and BP. It was found that each countryʼs pharmacopoeia described a detection test for substances related to VPA. It can be explained that VPA is derived from Valeric acid based on the test contents. Valeric acid is a component of Japanese Valeriana and Valerian root. It is believed that there is a sense of value as the origin of VPA is Japanese Valeriana and Valeriana root.

UI	MeSH Term	Description	Entries
D007600	Judgment	The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.	Judgement,Judgements,Judgments
D010421	Pentanoic Acids	Straight-chain CARBOXYLIC ACIDS with the general formula C5H10O2.	Acids, Pentanoic
D010602	Pharmacopoeias as Topic	Works about authoritative treatises on drugs and preparations, their description, formulation, analytic composition, physical constants, main chemical properties used in identification, standards for strength, purity, and dosage, chemical tests for determining identity and purity, etc.	Formulary, National,National Formulary,Formularies, National,National Formularies
D011619	Psychotropic Drugs	A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).	Psychoactive Agent,Psychoactive Agents,Psychoactive Drug,Psychopharmaceutical,Psychopharmaceuticals,Psychotropic Drug,Psychoactive Drugs,Agent, Psychoactive,Agents, Psychoactive,Drug, Psychoactive,Drug, Psychotropic,Drugs, Psychoactive,Drugs, Psychotropic
D014632	Valerian	A plant genus of the family VALERIANACEAE, order Dipsacales, subclass Asteridae, class Magnoliopsida. It is best known for the sedative use and valepotriate content of the roots. It is sometimes called Garden Heliotrope but is unrelated to true Heliotrope (HELIOTROPIUM).	Heliotrope, Garden,Valeriana,Valeriana officinalis,Garden Heliotrope,Garden Heliotropes,Heliotropes, Garden,Valeriana officinali,Valerianas,Valerians,officinalis, Valeriana
D014635	Valproic Acid	A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.	Dipropyl Acetate,Divalproex,Sodium Valproate,2-Propylpentanoic Acid,Calcium Valproate,Convulsofin,Depakene,Depakine,Depakote,Divalproex Sodium,Ergenyl,Magnesium Valproate,Propylisopropylacetic Acid,Semisodium Valproate,Valproate,Valproate Calcium,Valproate Sodium,Valproic Acid, Sodium Salt (2:1),Vupral,2 Propylpentanoic Acid