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The effect of serum of rabbits receiving an atherogenic diet on the biosynthesis of antibodies in intact animals was studied. The serum of rabbit kept on atherogenic diets for 6 weeks produced no effect upon the antibody formation when injected to intact rabbits simultanously with antigens. The serum of rabbits receiving cholesterol with their meals for 13 weeks stimulated antibody formation when injected simultaneously with antigens to intact animals. Incubation of the serum of rabbits kept on an atherogenic diet for 13 weeks with the polyvalent proteinase inhibitor Trasylol completely deprived it of its immunostimulating properties.
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