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Angiotensin II (AII) receptors in adrenal glomerulosa cells are coupled to adenylate cyclase inhibition. We investigated the importance of cyclase inhibition in adrenal steroidogenesis by treating adrenal glomerulosa cells with the toxin of Bordetella pertussis (20 ng/ml) for 3 and 18 h. This treatment prevented inhibition of forskolin-stimulated adenylate cyclase by AII. However, the aldosterone response to AII was not altered by toxin treatment. These results strongly suggest that adenylate cyclase inhibition is not directly involved in mediating the adrenal actions of AII. In addition, ACTH-induced steroidogenesis also was unaffected by toxin treatment demonstrating that cyclase inhibition is not involved in suppressing steroidogenesis via the cAMP pathway.
E A Woodcock, and
J K McLeod
July 1984,
Endocrinology,
E A Woodcock, and
J K McLeod
August 1983,
FEBS letters,
E A Woodcock, and
J K McLeod
January 1976,
Naunyn-Schmiedeberg's archives of pharmacology,
E A Woodcock, and
J K McLeod
November 1982,
Endocrinology,
E A Woodcock, and
J K McLeod
January 1987,
Endocrine research,
E A Woodcock, and
J K McLeod
June 1978,
Endocrinology,
E A Woodcock, and
J K McLeod
December 1983,
Biochemical and biophysical research communications,
E A Woodcock, and
J K McLeod
August 1990,
Endocrinologia japonica,
E A Woodcock, and
J K McLeod
August 1993,
The Journal of pharmacology and experimental therapeutics,
E A Woodcock, and
J K McLeod
September 1988,
The Journal of endocrinology,
