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In model of chronic obstructive pulmonary disease induced in rats by 60-day intermittent exposure to nitrogen dioxide mast cells participation in the mechanism of bronchial smooth muscle contractile activity patterns was evaluated. Since the 31st day, one group of rats was inhaled with sodium cromoglycate every day before the nitrogen dioxide exposure to stabilize the mast cell membrane. The other group (control) hasn’t been treated. Isometric contraction of the bronchial isolated preparations in response to nerve or smooth muscle stimulation were determined. Inhibition of mast cell degranulation and the release of endogenous histamine by stabilizing cell membranes prevented the development of bronchial smooth muscle hyperactivity caused by prolonged inhalation of nitrogen dioxide. It is believed that a mechanism to increase the contractile activity of the bronchial wall smooth muscles is mediated by activation of the transmembrane adenosine receptor in resident mast cells, leading to their partial degranulation with release of histamine, acting on the histamine Hl-receptors with the launch of reflex pathways through intramural ganglion neurons.
N A Kuzubova, and
A N Fedin, and
E S Lebedeva, and
O N Titova
July 1993,
The American review of respiratory disease,
N A Kuzubova, and
A N Fedin, and
E S Lebedeva, and
O N Titova
June 1990,
Israel journal of medical sciences,
N A Kuzubova, and
A N Fedin, and
E S Lebedeva, and
O N Titova
January 1983,
Stomatologia,
N A Kuzubova, and
A N Fedin, and
E S Lebedeva, and
O N Titova
August 1951,
Postgraduate medicine,
N A Kuzubova, and
A N Fedin, and
E S Lebedeva, and
O N Titova
January 2005,
Advances in immunology,
N A Kuzubova, and
A N Fedin, and
E S Lebedeva, and
O N Titova
January 1987,
Respiration; international review of thoracic diseases,
N A Kuzubova, and
A N Fedin, and
E S Lebedeva, and
O N Titova
January 1993,
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace,
N A Kuzubova, and
A N Fedin, and
E S Lebedeva, and
O N Titova
January 2022,
Medical principles and practice : international journal of the Kuwait University, Health Science Centre,
N A Kuzubova, and
A N Fedin, and
E S Lebedeva, and
O N Titova
March 2004,
Versicherungsmedizin,
N A Kuzubova, and
A N Fedin, and
E S Lebedeva, and
O N Titova
February 1984,
The American review of respiratory disease,
