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Experimental induction of simian acquired immune deficiency syndrome (SAIDS) by inoculation of juvenile rhesus monkeys with a type D retrovirus was prevented by immunization with Formalin-killed whole SAIDS retrovirus serotype 1 containing the adjuvant threonyl muramyl-dipeptide. All six immunized animals developed neutralizing antibody after three injections, while six age-matched cagemates receiving adjuvant alone were antibody free. All 12 monkeys were challenged intravenously with a potentially lethal dose of SAIDS retrovirus serotype 1. The six immunized animals failed to develop persistent viremia and remained clinically normal 8 months postchallenge. In contrast, five of six nonvaccinates developed persistent viremia, four of six developed clinical SAIDS, and two of six died with SAIDS at 10 weeks and 8 months postchallenge, respectively. These results show that prevention of a common spontaneous retrovirus-induced immunosuppressive disease in macaques is now possible by vaccination.
P A Marx, and
N C Pedersen, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
A A Lackner, and
D H Maul, and
H S Kwang, and
J D Kluge, and
C P Zaiss
March 1986,
Science (New York, N.Y.),
P A Marx, and
N C Pedersen, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
A A Lackner, and
D H Maul, and
H S Kwang, and
J D Kluge, and
C P Zaiss
August 1986,
Journal of the National Cancer Institute,
P A Marx, and
N C Pedersen, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
A A Lackner, and
D H Maul, and
H S Kwang, and
J D Kluge, and
C P Zaiss
October 1987,
Journal of virology,
P A Marx, and
N C Pedersen, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
A A Lackner, and
D H Maul, and
H S Kwang, and
J D Kluge, and
C P Zaiss
December 1986,
Clinical immunology and immunopathology,
P A Marx, and
N C Pedersen, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
A A Lackner, and
D H Maul, and
H S Kwang, and
J D Kluge, and
C P Zaiss
November 1985,
Journal of virology,
P A Marx, and
N C Pedersen, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
A A Lackner, and
D H Maul, and
H S Kwang, and
J D Kluge, and
C P Zaiss
April 1986,
Virology,
P A Marx, and
N C Pedersen, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
A A Lackner, and
D H Maul, and
H S Kwang, and
J D Kluge, and
C P Zaiss
December 1984,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
P A Marx, and
N C Pedersen, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
A A Lackner, and
D H Maul, and
H S Kwang, and
J D Kluge, and
C P Zaiss
February 1986,
Laboratory animal science,
P A Marx, and
N C Pedersen, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
A A Lackner, and
D H Maul, and
H S Kwang, and
J D Kluge, and
C P Zaiss
November 1986,
The Journal of clinical investigation,
P A Marx, and
N C Pedersen, and
N W Lerche, and
K G Osborn, and
L J Lowenstine, and
A A Lackner, and
D H Maul, and
H S Kwang, and
J D Kluge, and
C P Zaiss
October 1987,
Journal of the National Cancer Institute,
