Biomaterial Database

Early effect of myo-inositol deficiency on phosphatidylinositol metabolism in rat liver. 1987

L L Anderson, and M Trinh, and P K Flick

Young rats (100 g) were fed either a myo-inositol-deficient or supplemented (control) diet for up to 14 days following a 12 h fast. At various times during this period animals were killed, livers were removed, and a microsomal fraction was prepared and assayed for CDPdiacylglycerol inositol transferase activity and for phosphatidylinositol-inositol exchange activity. Within 2 days after beginning the regimen, rats consuming the deficient diet had a 40% lower activity of the transferase than rats consuming the control diet. This difference was maintained throughout the feeding period and developed simultaneously with the accumulation of triacylglycerol in the deficient livers. In contrast, the specific activity of the exchange enzyme was unchanged by feeding the deficient diet.

UI	MeSH Term	Description	Entries
D007294	Inositol	An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.	Myoinositol,Chiro-Inositol,Mesoinositol,Chiro Inositol
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008565	Membrane Proteins	Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.	Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D010716	Phosphatidylinositols	Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to the hexahydroxy alcohol, myo-inositol. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid, myo-inositol, and 2 moles of fatty acids.	Inositide Phospholipid,Inositol Phosphoglyceride,Inositol Phosphoglycerides,Inositol Phospholipid,Phosphoinositide,Phosphoinositides,PtdIns,Inositide Phospholipids,Inositol Phospholipids,Phosphatidyl Inositol,Phosphatidylinositol,Inositol, Phosphatidyl,Phosphoglyceride, Inositol,Phosphoglycerides, Inositol,Phospholipid, Inositide,Phospholipid, Inositol,Phospholipids, Inositide,Phospholipids, Inositol
D010770	Phosphotransferases	A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.	Kinases,Phosphotransferase,Phosphotransferases, ATP,Transphosphorylase,Transphosphorylases,Kinase,ATP Phosphotransferases
D002352	Carrier Proteins	Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes.	Binding Proteins,Carrier Protein,Transport Protein,Transport Proteins,Binding Protein,Protein, Carrier,Proteins, Carrier
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D049294	Phospholipid Transfer Proteins	A ubiquitous family of proteins that transport PHOSPHOLIPIDS such as PHOSPHATIDYLINOSITOL and PHOSPHATIDYLCHOLINE between membranes. They play an important role in phospholipid metabolism during vesicular transport and SIGNAL TRANSDUCTION.	Phosphatidylinositol Transfer Proteins,Aminophospholipid Flippase,Aminophospholipid Transfer Proteins,Aminophospholipid Translocase,Aminophospholipid Translocator,Aminophospholipid Transporter,Lecithin Transfer Protein,Nonspecific Phospholipid Transfer proteins,Phosphatidyl Transfer Protein,Phosphatidylcholine Exchange Protein,Phosphatidylcholine Transfer Protein,Phosphatidylcholine Transfer Proteins,Phosphatidylinositol Exchange Protein,Phosphatidylinositol Transfer Protein,Phosphatidylinositol Transfer Protein alpha,Phosphatidylinositol Transfer Protein beta,Phosphatidylserine Translocase,Phospholipid Exchange Protein,Phospholipid Exchange Proteins,Phospholipid Scramblase,Phospholipid Transfer Protein,Phospholipid Translocating Protein,Scramblase, Phospholipid,Transfer Proteins, Phospholipid,Translocase, Aminophospholipid,Translocase, Phosphatidylserine,Translocator, Aminophospholipid,Transporter, Aminophospholipid
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D051607	CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase	An enzyme that catalyzes the formation of PHOSPHATIDYLINOSITOL and CMP from CDP-DIACYLGLYCEROL and MYOINOSITOL.	CDP-1,2-Diacyl-sn-Glycerol-Myoinositol 3-Phosphatidyltransferase,CDP-DG Inositol Transferase,CDP-Diacylglycerol-Myo-Inositol 3-Phosphatidyltransferase,CDP-Diglyceride-Inositol Transferase,CDP-Diglyceride-Inositoltransferase,CDPdiacylglycerol-Inositol 3-Phosphatidyltransferase,CDPdiglyceride-Inositol Phosphatidyltransferase,Cytidine 5'-Diphosphate 1,2-Diacyl-sn-Glycerol - Inositol Transferase,Inositol Phosphatidyltransferase,Phosphatidylinositol Synthase,3-Phosphatidyltransferase, CDP-1,2-Diacyl-sn-Glycerol-Myoinositol,3-Phosphatidyltransferase, CDP-Diacylglycerol-Inositol,3-Phosphatidyltransferase, CDP-Diacylglycerol-Myo-Inositol,3-Phosphatidyltransferase, CDPdiacylglycerol-Inositol,CDP 1,2 Diacyl sn Glycerol Myoinositol 3 Phosphatidyltransferase,CDP DG Inositol Transferase,CDP Diacylglycerol Inositol 3 Phosphatidyltransferase,CDP Diacylglycerol Myo Inositol 3 Phosphatidyltransferase,CDP Diglyceride Inositol Transferase,CDP Diglyceride Inositoltransferase,CDPdiacylglycerol Inositol 3 Phosphatidyltransferase,CDPdiglyceride Inositol Phosphatidyltransferase,Cytidine 5' Diphosphate 1,2 Diacyl sn Glycerol Inositol Transferase,Phosphatidyltransferase, CDPdiglyceride-Inositol,Phosphatidyltransferase, Inositol