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In this study we provide evidence that distinct DNA sequences within the 5'-flanking regions of the genes for interleukin-2 (IL-2) and its receptor (IL-2R) are involved in human T-cell-specific activation of transcription by p40x, a product of human T cell leukemia virus type I (HTLV-1). The same DNA sequences appear to be responsible for induction of the genes in a T cell line, Jurkat, by mitogens. Although the IL-2 gene sequences are activated by p40x with much lower efficiency than the IL-2R gene sequences, they are synergistically activated by the p40x expression and subsequent extracellular stimulation by Concanavalin-A or anti-T3. We propose a model for two-step activation of the IL-2 autocrine loop in ATL development.
M Maruyama, and
H Shibuya, and
H Harada, and
M Hatakeyama, and
M Seiki, and
T Fujita, and
J Inoue, and
M Yoshida, and
T Taniguchi
March 1984,
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M Maruyama, and
H Shibuya, and
H Harada, and
M Hatakeyama, and
M Seiki, and
T Fujita, and
J Inoue, and
M Yoshida, and
T Taniguchi
November 1986,
The EMBO journal,
M Maruyama, and
H Shibuya, and
H Harada, and
M Hatakeyama, and
M Seiki, and
T Fujita, and
J Inoue, and
M Yoshida, and
T Taniguchi
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Nature,
M Maruyama, and
H Shibuya, and
H Harada, and
M Hatakeyama, and
M Seiki, and
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M Maruyama, and
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T Taniguchi
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