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Activities of six lysosomal enzymes in the cerebellum of jaundiced homozygous (jj) Gunn rats were examined from 5 to 20 days of life and compared with those in heterozygotes (j+). Significantly higher enzyme activities were first detected at 8 days. The jj/j+ activity ratios of all enzymes peaked at 15 days. The ratios of beta-glycerophosphatase, beta-mannosidase, and acid lipase were only 1.3-1.7, whereas those of arylsulfatase and cathepsin were 2.0 and 3.1, respectively. The most striking increase in activity was observed with beta-glucuronidase, the ratio of which was 8.4. These results indicate a selective increase in activities of certain lysosomal enzymes in the hypoplastic cerebellum of jj rats.
H Sato, and
H Keino, and
S Aono, and
R Semba, and
S Kashiwamata
June 1983,
Neurochemical research,
H Sato, and
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February 1977,
Physiology & behavior,
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October 1983,
Experientia,
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May 1997,
Acta neuropathologica,
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October 1980,
Experientia,
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February 1989,
Neuroscience research,
H Sato, and
H Keino, and
S Aono, and
R Semba, and
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January 1989,
Biology of the neonate,
H Sato, and
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November 1990,
Neuroscience research,
H Sato, and
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March 1988,
Journal of neurochemistry,
H Sato, and
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January 1984,
Neurochemical pathology,
