Microwave characterization of low-molecular-weight antioxidant specific biomarkers. 2019

Natalia Naumova, and Hanna Hlukhova, and Alexander Barannik, and Alexey Gubin, and Irina Protsenko, and Nickolay Cherpak, and Svetlana Vitusevich
Forschungszentrum Jülich, Bioelectronics (ICS-8), Jülich 52425, Germany.

Antioxidants play a crucial role in the life sciences, as the regulators of biochemical reactions. We studied the dielectric properties of the low-molecular weight antioxidant specific biomarkers sodium ascorbate and glutathione in solutions of different concentrations. The biomarkers are multifunctional metabolites relevant to the reactive oxygen species (ROS) scavenging system of cells. The newly developed high-Q microwave whispering-gallery-mode (WGM) dielectric resonator based technique was applied. The technique allows investigation of liquids of nanoliter volumes filled in microfluidic channel within several milliseconds. The revealed peculiarities in the dependence of permittivity on concentrations of the sodium ascorbate and glutathione solutions are explained by differences in relaxation times and loses introduced by molecules of different shapes. We suggest that this novel approach offers the potential for the detection and characterization of ROS-relevant biomarkers with millisecond-time resolution.

UI MeSH Term Description Entries
D008872 Microwaves That portion of the electromagnetic spectrum from the UHF (ultrahigh frequency) radio waves and extending into the INFRARED RAYS frequencies. EHF Waves,Extremely High Frequency Radio Waves,Micro Wave,Micro Waves,Ultrahigh Frequency Waves,Microwave Radiation,EHF Wave,Micro Waves,Microwave,Microwave Radiations,Radiation, Microwave,Ultrahigh Frequency Wave,Wave, EHF,Wave, Micro,Wave, Ultrahigh Frequency,Waves, Micro
D008970 Molecular Weight The sum of the weight of all the atoms in a molecule. Molecular Weights,Weight, Molecular,Weights, Molecular
D003198 Computer Simulation Computer-based representation of physical systems and phenomena such as chemical processes. Computational Modeling,Computational Modelling,Computer Models,In silico Modeling,In silico Models,In silico Simulation,Models, Computer,Computerized Models,Computer Model,Computer Simulations,Computerized Model,In silico Model,Model, Computer,Model, Computerized,Model, In silico,Modeling, Computational,Modeling, In silico,Modelling, Computational,Simulation, Computer,Simulation, In silico,Simulations, Computer
D004563 Electrochemistry The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes. Electrochemistries
D005978 Glutathione A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. Reduced Glutathione,gamma-L-Glu-L-Cys-Gly,gamma-L-Glutamyl-L-Cysteinylglycine,Glutathione, Reduced,gamma L Glu L Cys Gly,gamma L Glutamyl L Cysteinylglycine
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000975 Antioxidants Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. Anti-Oxidant,Antioxidant,Antioxidant Activity,Endogenous Antioxidant,Endogenous Antioxidants,Anti-Oxidant Effect,Anti-Oxidant Effects,Anti-Oxidants,Antioxidant Effect,Antioxidant Effects,Activity, Antioxidant,Anti Oxidant,Anti Oxidant Effect,Anti Oxidant Effects,Anti Oxidants,Antioxidant, Endogenous,Antioxidants, Endogenous
D001205 Ascorbic Acid A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. Vitamin C,Ascorbic Acid, Monosodium Salt,Ferrous Ascorbate,Hybrin,L-Ascorbic Acid,Magnesium Ascorbate,Magnesium Ascorbicum,Magnesium di-L-Ascorbate,Magnorbin,Sodium Ascorbate,Acid, Ascorbic,Acid, L-Ascorbic,Ascorbate, Ferrous,Ascorbate, Magnesium,Ascorbate, Sodium,L Ascorbic Acid,Magnesium di L Ascorbate,di-L-Ascorbate, Magnesium
D015415 Biomarkers Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, ENVIRONMENTAL EXPOSURE and its effects, disease diagnosis; METABOLIC PROCESSES; SUBSTANCE ABUSE; PREGNANCY; cell line development; EPIDEMIOLOGIC STUDIES; etc. Biochemical Markers,Biological Markers,Biomarker,Clinical Markers,Immunologic Markers,Laboratory Markers,Markers, Biochemical,Markers, Biological,Markers, Clinical,Markers, Immunologic,Markers, Laboratory,Markers, Serum,Markers, Surrogate,Markers, Viral,Serum Markers,Surrogate Markers,Viral Markers,Biochemical Marker,Biologic Marker,Biologic Markers,Clinical Marker,Immune Marker,Immune Markers,Immunologic Marker,Laboratory Marker,Marker, Biochemical,Marker, Biological,Marker, Clinical,Marker, Immunologic,Marker, Laboratory,Marker, Serum,Marker, Surrogate,Serum Marker,Surrogate End Point,Surrogate End Points,Surrogate Endpoint,Surrogate Endpoints,Surrogate Marker,Viral Marker,Biological Marker,End Point, Surrogate,End Points, Surrogate,Endpoint, Surrogate,Endpoints, Surrogate,Marker, Biologic,Marker, Immune,Marker, Viral,Markers, Biologic,Markers, Immune
D016014 Linear Models Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression. Linear Regression,Log-Linear Models,Models, Linear,Linear Model,Linear Regressions,Log Linear Models,Log-Linear Model,Model, Linear,Model, Log-Linear,Models, Log-Linear,Regression, Linear,Regressions, Linear

Related Publications

Natalia Naumova, and Hanna Hlukhova, and Alexander Barannik, and Alexey Gubin, and Irina Protsenko, and Nickolay Cherpak, and Svetlana Vitusevich
November 2019, Biomolecules,
Natalia Naumova, and Hanna Hlukhova, and Alexander Barannik, and Alexey Gubin, and Irina Protsenko, and Nickolay Cherpak, and Svetlana Vitusevich
October 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Natalia Naumova, and Hanna Hlukhova, and Alexander Barannik, and Alexey Gubin, and Irina Protsenko, and Nickolay Cherpak, and Svetlana Vitusevich
September 2019, International journal of biological macromolecules,
Natalia Naumova, and Hanna Hlukhova, and Alexander Barannik, and Alexey Gubin, and Irina Protsenko, and Nickolay Cherpak, and Svetlana Vitusevich
June 2015, ACS nano,
Natalia Naumova, and Hanna Hlukhova, and Alexander Barannik, and Alexey Gubin, and Irina Protsenko, and Nickolay Cherpak, and Svetlana Vitusevich
January 2012, Handbook of experimental pharmacology,
Natalia Naumova, and Hanna Hlukhova, and Alexander Barannik, and Alexey Gubin, and Irina Protsenko, and Nickolay Cherpak, and Svetlana Vitusevich
March 1995, Journal of pharmaceutical sciences,
Natalia Naumova, and Hanna Hlukhova, and Alexander Barannik, and Alexey Gubin, and Irina Protsenko, and Nickolay Cherpak, and Svetlana Vitusevich
August 2003, Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology,
Natalia Naumova, and Hanna Hlukhova, and Alexander Barannik, and Alexey Gubin, and Irina Protsenko, and Nickolay Cherpak, and Svetlana Vitusevich
January 1999, Seminars in thrombosis and hemostasis,
Natalia Naumova, and Hanna Hlukhova, and Alexander Barannik, and Alexey Gubin, and Irina Protsenko, and Nickolay Cherpak, and Svetlana Vitusevich
January 2003, Free radical biology & medicine,
Natalia Naumova, and Hanna Hlukhova, and Alexander Barannik, and Alexey Gubin, and Irina Protsenko, and Nickolay Cherpak, and Svetlana Vitusevich
March 1967, Biochimica et biophysica acta,
Copied contents to your clipboard!