Telomerase Reverse Transcriptase Expression in Mouse Endometrium During Reepithelialization and Regeneration in a Menses-Like Model. 2019

Fiona L Cousins, and Dorien F O, and Yih Rue Ong, and David T Breault, and James A Deane, and Caroline E Gargett
1 The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia.

The regenerative capacity of the endometrium has been attributed to resident stem/progenitor cells. A number of stem/progenitor markers have been reported for human endometrial stem/progenitor cells; however, the lack of convenient markers in the mouse has made experimental investigation into endometrial regeneration difficult. We recently identified endometrial epithelial, endothelial, and immune cells, which express a reporter for the stem/progenitor marker, mouse telomerase reverse transcriptase (mTert). In this study, we investigate the expression pattern of a green fluorescent protein (GFP) reporter for mTert promoter activity (mTert-GFP) in endometrial regeneration following a menses-like event. mTert-GFP expression marks subepithelial populations of T cells and mature macrophages and may play a role in immune cell regulated repair. Clusters of mTert-GFP-positive epithelial cells were identified close to areas of reepithelialization and possibly highlight a role for mTert in the repair and regeneration of the endometrial epithelium.

UI MeSH Term Description Entries
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D004717 Endometrium The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo. Endometria
D004847 Epithelial Cells Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells. Adenomatous Epithelial Cells,Columnar Glandular Epithelial Cells,Cuboidal Glandular Epithelial Cells,Glandular Epithelial Cells,Squamous Cells,Squamous Epithelial Cells,Transitional Epithelial Cells,Adenomatous Epithelial Cell,Cell, Adenomatous Epithelial,Cell, Epithelial,Cell, Glandular Epithelial,Cell, Squamous,Cell, Squamous Epithelial,Cell, Transitional Epithelial,Cells, Adenomatous Epithelial,Cells, Epithelial,Cells, Glandular Epithelial,Cells, Squamous,Cells, Squamous Epithelial,Cells, Transitional Epithelial,Epithelial Cell,Epithelial Cell, Adenomatous,Epithelial Cell, Glandular,Epithelial Cell, Squamous,Epithelial Cell, Transitional,Epithelial Cells, Adenomatous,Epithelial Cells, Glandular,Epithelial Cells, Squamous,Epithelial Cells, Transitional,Glandular Epithelial Cell,Squamous Cell,Squamous Epithelial Cell,Transitional Epithelial Cell
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D062326 Re-Epithelialization Reconstitution of eroded or injured EPITHELIUM by proliferation and migration of EPITHELIAL CELLS from below or adjacent to the damaged site. Wound Epithelialization,Epithelialization, Wound,Re Epithelialization
D019098 Telomerase An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES. Telomerase Catalytic Subunit,Telomerase Reverse Transcriptase,Telomerase Reverse Transcriptase Catalytic Subunit,Catalytic Subunit, Telomerase,Reverse Transcriptase, Telomerase,Subunit, Telomerase Catalytic,Transcriptase, Telomerase Reverse
D030762 Estrous Cycle The period of cyclic physiological and behavior changes in non-primate female mammals that exhibit ESTRUS. The estrous cycle generally consists of 4 or 5 distinct periods corresponding to the endocrine status (PROESTRUS; ESTRUS; METESTRUS; DIESTRUS; and ANESTRUS). Cycle, Estrous,Cycles, Estrous,Estrous Cycles

Related Publications

Fiona L Cousins, and Dorien F O, and Yih Rue Ong, and David T Breault, and James A Deane, and Caroline E Gargett
April 1998, Oncogene,
Fiona L Cousins, and Dorien F O, and Yih Rue Ong, and David T Breault, and James A Deane, and Caroline E Gargett
March 2007, Human reproduction (Oxford, England),
Fiona L Cousins, and Dorien F O, and Yih Rue Ong, and David T Breault, and James A Deane, and Caroline E Gargett
October 2017, Experimental neurobiology,
Fiona L Cousins, and Dorien F O, and Yih Rue Ong, and David T Breault, and James A Deane, and Caroline E Gargett
February 1999, Journal of gastroenterology,
Fiona L Cousins, and Dorien F O, and Yih Rue Ong, and David T Breault, and James A Deane, and Caroline E Gargett
January 2006, World journal of gastroenterology,
Fiona L Cousins, and Dorien F O, and Yih Rue Ong, and David T Breault, and James A Deane, and Caroline E Gargett
January 2012, Indian journal of pathology & microbiology,
Fiona L Cousins, and Dorien F O, and Yih Rue Ong, and David T Breault, and James A Deane, and Caroline E Gargett
July 2002, American journal of respiratory and critical care medicine,
Fiona L Cousins, and Dorien F O, and Yih Rue Ong, and David T Breault, and James A Deane, and Caroline E Gargett
January 2011, Proceedings of the National Academy of Sciences of the United States of America,
Fiona L Cousins, and Dorien F O, and Yih Rue Ong, and David T Breault, and James A Deane, and Caroline E Gargett
December 2017, Experimental neurobiology,
Fiona L Cousins, and Dorien F O, and Yih Rue Ong, and David T Breault, and James A Deane, and Caroline E Gargett
April 2016, Molecular human reproduction,
Copied contents to your clipboard!