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Proton release from HeLa cells is stimulated by external oxidants for the transplasmalemma electron transport enzymes. These oxidants, such as ferricyanide and diferric transferrin, also stimulate cell growth. We now present evidence that proton release associated with the reduction of ferricyanide and diferric transferrin is through the Na+/H+ antiport. The stoichiometry of H+/e- release with diferric transferrin is over 50 to 1, which is greater than expected for oxidation of a protonated transmembrane electron carrier. Diferric transferrin induced proton release depends on external sodium and is inhibited by amiloride. Proton release is also inhibited when diferric transferrin reduction is inhibited by apotransferrin. A tightly coupled association between the redox system and the antiport is shown by sodium dependence and amiloride inhibition of diferric transferrin reduction. The results indicate a new role for ferric transferrin in growth stimulation by activation of the sodium-proton antiport.
I L Sun, and
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W Liu, and
W Toole-Simms, and
F L Crane, and
D J Morré, and
H Löw
February 1988,
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H Löw
April 1991,
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I L Sun, and
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H Löw
October 1990,
Gastroenterology,
I L Sun, and
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W Toole-Simms, and
F L Crane, and
D J Morré, and
H Löw
January 1994,
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I L Sun, and
R Garcia-Cañero, and
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W Toole-Simms, and
F L Crane, and
D J Morré, and
H Löw
December 1986,
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April 1992,
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H Löw
May 1995,
The American journal of physiology,
I L Sun, and
R Garcia-Cañero, and
W Liu, and
W Toole-Simms, and
F L Crane, and
D J Morré, and
H Löw
June 1987,
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I L Sun, and
R Garcia-Cañero, and
W Liu, and
W Toole-Simms, and
F L Crane, and
D J Morré, and
H Löw
August 1988,
Biochimica et biophysica acta,
I L Sun, and
R Garcia-Cañero, and
W Liu, and
W Toole-Simms, and
F L Crane, and
D J Morré, and
H Löw
May 1987,
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