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Eleven of 25 rhesus monkeys which died of simian acquired immunodeficiency syndrome (SAIDS) caused by infection with a type D retrovirus related to Mason-Pfizer monkey virus showed evidence of muscle weakness and atrophy and had elevated levels of muscle enzymes. Biopsies of affected muscle studied with enzyme histochemistry showed the characteristic features of polymyositis. Inflammatory cells consisting of lymphocytes, macrophages, and large vacuolated bizarre-shaped cells of undetermined type were surrounding or invading muscle fibers and were present in the perivascular spaces and endomysia septa. Within the perivascular infiltrates, lymphocytes were abundant but very few macrophages were present. Other myopathic features including profound proliferation of fibrous tissue, necrosis, and phagocytosis of muscle fibers were noted to a variable degree. The retrovirus was isolated from affected muscles. The clinical and historical features of polymyositis in rhesus monkeys with SAIDS are very similar to those of human polymyositis. The polymyositis in SAIDS induced by a type D retrovirus related to Mason-Pfizer monkey virus is an excellent primate model to study the mechanism and morphological changes of viral-induced muscle damage.
M C Dalakas, and
M Gravell, and
W T London, and
G Cunningham, and
J L Sever
June 1992,
The American journal of pathology,
M C Dalakas, and
M Gravell, and
W T London, and
G Cunningham, and
J L Sever
July 1986,
Journal of the National Cancer Institute,
M C Dalakas, and
M Gravell, and
W T London, and
G Cunningham, and
J L Sever
April 1984,
Laboratory animal science,
M C Dalakas, and
M Gravell, and
W T London, and
G Cunningham, and
J L Sever
June 1985,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M C Dalakas, and
M Gravell, and
W T London, and
G Cunningham, and
J L Sever
April 1989,
Arthritis and rheumatism,
M C Dalakas, and
M Gravell, and
W T London, and
G Cunningham, and
J L Sever
November 1985,
Veterinary immunology and immunopathology,
M C Dalakas, and
M Gravell, and
W T London, and
G Cunningham, and
J L Sever
October 1991,
Laboratory investigation; a journal of technical methods and pathology,
M C Dalakas, and
M Gravell, and
W T London, and
G Cunningham, and
J L Sever
February 1983,
Lancet (London, England),
M C Dalakas, and
M Gravell, and
W T London, and
G Cunningham, and
J L Sever
November 1991,
The American journal of pathology,
M C Dalakas, and
M Gravell, and
W T London, and
G Cunningham, and
J L Sever
January 1986,
Progress in allergy,
