Biomaterial Database

Negative pion irradiation of mammalian cells. II. A comparative analysis of cell-cycle progression after exposure to pi-mesons and cobalt gamma-rays. 1978

H Schlag, and K F Weibezahn, and C Lücke-Huhle

The effect of negative pi-mesons on cell-cycle progression of exponentially-growing V 79 monolayer cultures was examined by flow-microfluorometric analysis. Comparison with proliferative changes of the same cell-line after cobalt gamma-irradiation yielded r.b.e. values (relative biological effectiveness) of 2.2 for both, G2+M accumulation and division delay after irradiation at the pion peak. A dose-dependent prolongation of S-phase was found after Co gamma-irradiation which, however, was not detectable after pi-exposure. This observation is so far the only qualitative difference demonstrated in the effects of the two types of radiation.

UI	MeSH Term	Description	Entries
D012062	Relative Biological Effectiveness	The ratio of radiation dosages required to produce identical change based on a formula comparing other types of radiation with that of gamma or roentgen rays.	Biological Effectiveness, Relative,Effectiveness, Biologic Relative,Effectiveness, Biological Relative,Relative Biologic Effectiveness,Biologic Effectiveness, Relative,Biologic Relative Effectiveness,Biological Relative Effectiveness,Effectiveness, Relative Biologic,Effectiveness, Relative Biological,Relative Effectiveness, Biologic
D002453	Cell Cycle	The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.	Cell Division Cycle,Cell Cycles,Cell Division Cycles,Cycle, Cell,Cycle, Cell Division,Cycles, Cell,Cycles, Cell Division,Division Cycle, Cell,Division Cycles, Cell
D002470	Cell Survival	The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.	Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D003037	Cobalt Radioisotopes	Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.	Radioisotopes, Cobalt
D004307	Dose-Response Relationship, Radiation	The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.	Dose Response Relationship, Radiation,Dose-Response Relationships, Radiation,Radiation Dose-Response Relationship,Radiation Dose-Response Relationships,Relationship, Radiation Dose-Response,Relationships, Radiation Dose-Response
D004601	Elementary Particles	Individual components of atoms, usually subatomic; subnuclear particles are usually detected only when the atomic nucleus decays and then only transiently, as most of them are unstable, often yielding pure energy without substance, i.e., radiation.	Baryons,Fundamental Particles,Baryon,Elementary Particle,Fundamental Particle,Particle, Elementary,Particle, Fundamental,Particles, Elementary,Particles, Fundamental
D005720	Gamma Rays	Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.	Gamma Wave,Gamma Radiation,Nuclear X-Rays,Radiation, Gamma,X-Rays, Nuclear,Gamma Radiations,Gamma Ray,Gamma Waves,Nuclear X Rays,Nuclear X-Ray,Ray, Gamma,Wave, Gamma,Waves, Gamma,X Rays, Nuclear,X-Ray, Nuclear
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor

Related Publications

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RELATIVE BIOLOGICAL EFFICIENCY OF NEGATIVE MU-MESONS AND COBALT-60 GAMMA-RAYS.

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Response of HeLa cells to irradiation with pi- mesons.

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Growth fraction and cell cycle time of gamma-rays irradiated mammalian cells.

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Response of multicellular tumor spheroids to multiple fractions of negative pi mesons and X rays.

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Changes in nuclease sensitivity of mammalian cells after irradiation with 60Co gamma-rays.

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Recovery in mammalian cells irradiated with a beam of pi--mesons.

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