Genetic characterization of an H13N2 low pathogenic avian influenza virus isolated from gulls in China. 2019

Zhijun Yu, and Hongbin He, and Kaihui Cheng, and Jiaqiang Wu, and Yuwei Gao, and Weijing Chen, and Xiaoyuan Yuan, and Yongkun Zhao
Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan, China.

Low pathogenic avian influenza viruses circulate in wild birds but are occasionally transmitted to other species, including poultry, mammals and humans. To date, infections with low pathogenic avian influenza viruses of HA subtype 6, HA subtype 7, HA subtype 9 and HA subtype 10 among humans have been reported. However, the epidemiology, genetics and ecology of low pathogenic avian influenza viruses have not been fully understood thus far. Therefore, persistent surveillance of low pathogenic avian influenza virus infections in wild birds and other species is needed. Here, we found a low pathogenic avian influenza virus of the subtype H13N2 (abbreviated as WH42) in black-tailed gulls in China. All gene sequences of this H13N2 virus were determined and used for subsequent analysis. Phylogenetic analysis of the HA gene and NA gene indicated that WH42 was derived from the Eurasian lineage. We analysed the timing of the reassortment events and found that WH42 was a reassortant whose genes were transferred from avian influenza viruses circulating in Asia, Europe and North America. Additionally, WH42 possessed several molecular markers associated with mammalian virulence and mammalian transmissibility. Interestingly, we also found low but detectable haemagglutination inhibition antibodies against H13N2 low pathogenic avian influenza virus in serum samples collected from chickens. Taken together, our findings show that the H13 virus may have been introduced into poultry and that sustainable surveillance in gulls and poultry is required.

UI MeSH Term Description Entries
D009439 Neuraminidase An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992) Sialidase,Exo-alpha-Sialidase,N-Acylneuraminate Glycohydrolases,Oligosaccharide Sialidase,Exo alpha Sialidase,Glycohydrolases, N-Acylneuraminate,N Acylneuraminate Glycohydrolases,Sialidase, Oligosaccharide
D009980 Influenza A virus The type species of the genus ALPHAINFLUENZAVIRUS that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces. Alphainfluenzavirus influenzae,Avian Orthomyxovirus Type A,FLUAV,Fowl Plague Virus,Human Influenza A Virus,Influenza Virus Type A,Influenza Viruses Type A,Myxovirus influenzae-A hominis,Myxovirus influenzae-A suis,Myxovirus pestis galli,Orthomyxovirus Type A,Orthomyxovirus Type A, Avian,Orthomyxovirus Type A, Human,Orthomyxovirus Type A, Porcine,Pestis galli Myxovirus,Fowl Plague Viruses,Influenza A viruses,Myxovirus influenzae A hominis,Myxovirus influenzae A suis,Myxovirus, Pestis galli,Myxoviruses, Pestis galli,Pestis galli Myxoviruses,Plague Virus, Fowl,Virus, Fowl Plague
D010802 Phylogeny The relationships of groups of organisms as reflected by their genetic makeup. Community Phylogenetics,Molecular Phylogenetics,Phylogenetic Analyses,Phylogenetic Analysis,Phylogenetic Clustering,Phylogenetic Comparative Analysis,Phylogenetic Comparative Methods,Phylogenetic Distance,Phylogenetic Generalized Least Squares,Phylogenetic Groups,Phylogenetic Incongruence,Phylogenetic Inference,Phylogenetic Networks,Phylogenetic Reconstruction,Phylogenetic Relatedness,Phylogenetic Relationships,Phylogenetic Signal,Phylogenetic Structure,Phylogenetic Tree,Phylogenetic Trees,Phylogenomics,Analyse, Phylogenetic,Analysis, Phylogenetic,Analysis, Phylogenetic Comparative,Clustering, Phylogenetic,Community Phylogenetic,Comparative Analysis, Phylogenetic,Comparative Method, Phylogenetic,Distance, Phylogenetic,Group, Phylogenetic,Incongruence, Phylogenetic,Inference, Phylogenetic,Method, Phylogenetic Comparative,Molecular Phylogenetic,Network, Phylogenetic,Phylogenetic Analyse,Phylogenetic Clusterings,Phylogenetic Comparative Analyses,Phylogenetic Comparative Method,Phylogenetic Distances,Phylogenetic Group,Phylogenetic Incongruences,Phylogenetic Inferences,Phylogenetic Network,Phylogenetic Reconstructions,Phylogenetic Relatednesses,Phylogenetic Relationship,Phylogenetic Signals,Phylogenetic Structures,Phylogenetic, Community,Phylogenetic, Molecular,Phylogenies,Phylogenomic,Reconstruction, Phylogenetic,Relatedness, Phylogenetic,Relationship, Phylogenetic,Signal, Phylogenetic,Structure, Phylogenetic,Tree, Phylogenetic
D011201 Poultry Diseases Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild. Disease, Poultry,Diseases, Poultry,Poultry Disease
D002645 Chickens Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA. Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D002681 China A country spanning from central Asia to the Pacific Ocean. Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D005585 Influenza in Birds Infection of domestic and wild fowl and other BIRDS with INFLUENZA A VIRUS. Avian influenza usually does not sicken birds, but can be highly pathogenic and fatal in domestic POULTRY. Avian Flu,Avian Influenza,Fowl Plague,Influenza, Avian,Avian Influenzas,Flu, Avian,Influenza in Bird,Influenzas, Avian,Plague, Fowl
D006385 Hemagglutination Inhibition Tests Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination. Hemagglutination Inhibition Test,Inhibition Test, Hemagglutination,Inhibition Tests, Hemagglutination,Test, Hemagglutination Inhibition,Tests, Hemagglutination Inhibition
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000835 Animals, Wild Animals considered to be wild or feral or not adapted for domestic use. It does not include wild animals in zoos for which ANIMALS, ZOO is available. Animals, Nondomestic,Animals, Nondomesticated,Animals, Feral,Stray Animals,Animal, Feral,Animal, Nondomestic,Animal, Nondomesticated,Animal, Stray,Animal, Wild,Animals, Stray,Feral Animal,Feral Animals,Nondomestic Animal,Nondomestic Animals,Nondomesticated Animal,Nondomesticated Animals,Stray Animal,Wild Animal,Wild Animals

Related Publications

Zhijun Yu, and Hongbin He, and Kaihui Cheng, and Jiaqiang Wu, and Yuwei Gao, and Weijing Chen, and Xiaoyuan Yuan, and Yongkun Zhao
January 2011, Influenza research and treatment,
Zhijun Yu, and Hongbin He, and Kaihui Cheng, and Jiaqiang Wu, and Yuwei Gao, and Weijing Chen, and Xiaoyuan Yuan, and Yongkun Zhao
February 2021, Poultry science,
Zhijun Yu, and Hongbin He, and Kaihui Cheng, and Jiaqiang Wu, and Yuwei Gao, and Weijing Chen, and Xiaoyuan Yuan, and Yongkun Zhao
December 2015, Emerging infectious diseases,
Zhijun Yu, and Hongbin He, and Kaihui Cheng, and Jiaqiang Wu, and Yuwei Gao, and Weijing Chen, and Xiaoyuan Yuan, and Yongkun Zhao
November 2020, The Journal of infection,
Zhijun Yu, and Hongbin He, and Kaihui Cheng, and Jiaqiang Wu, and Yuwei Gao, and Weijing Chen, and Xiaoyuan Yuan, and Yongkun Zhao
December 1998, Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology,
Zhijun Yu, and Hongbin He, and Kaihui Cheng, and Jiaqiang Wu, and Yuwei Gao, and Weijing Chen, and Xiaoyuan Yuan, and Yongkun Zhao
February 2009, Virus genes,
Zhijun Yu, and Hongbin He, and Kaihui Cheng, and Jiaqiang Wu, and Yuwei Gao, and Weijing Chen, and Xiaoyuan Yuan, and Yongkun Zhao
June 2010, Biochemical and biophysical research communications,
Zhijun Yu, and Hongbin He, and Kaihui Cheng, and Jiaqiang Wu, and Yuwei Gao, and Weijing Chen, and Xiaoyuan Yuan, and Yongkun Zhao
December 2023, The Journal of infection,
Zhijun Yu, and Hongbin He, and Kaihui Cheng, and Jiaqiang Wu, and Yuwei Gao, and Weijing Chen, and Xiaoyuan Yuan, and Yongkun Zhao
March 2021, The Journal of infection,
Zhijun Yu, and Hongbin He, and Kaihui Cheng, and Jiaqiang Wu, and Yuwei Gao, and Weijing Chen, and Xiaoyuan Yuan, and Yongkun Zhao
January 2023, Frontiers in microbiology,
Copied contents to your clipboard!