-transparent.png){kind=logo}
Two hundred eighty-one patients with the acquired immunodeficiency syndrome (AIDS) or advanced AIDS-related complex were enrolled in a double-blind, placebo-controlled trial of the efficacy and safety of orally administered zidovudine (azidothymidine or AZT). Significant clinical benefits and adverse experiences have been reported from this trial. Because neuropsychiatric dysfunction is often associated with human immunodeficiency virus (HIV) infection, a brief affective and neuropsychological examination was administered over 16 weeks of the trial to evaluate any changes in neuropsychological function that occurred with drug administration. Patients receiving zidovudine, particularly those with AIDS, showed improved cognition as compared with patients receiving placebo. There were no changes in affective symptoms. The zidovudine recipients also had a statistically significant reduction in the intensity of symptomatic distress during the trial that may account in part for the observed cognitive changes. Some improvement in various cognitive measures was also seen in patients with AIDS-related complex. The results of this study suggest HIV-associated cognitive abnormalities may be partially ameliorated after the administration of zidovudine.
F A Schmitt, and
J W Bigley, and
R McKinnis, and
P E Logue, and
R W Evans, and
J L Drucker
November 1989,
JAMA,
F A Schmitt, and
J W Bigley, and
R McKinnis, and
P E Logue, and
R W Evans, and
J L Drucker
February 1989,
Hospital practice (Office ed.),
F A Schmitt, and
J W Bigley, and
R McKinnis, and
P E Logue, and
R W Evans, and
J L Drucker
August 1990,
AIDS (London, England),
F A Schmitt, and
J W Bigley, and
R McKinnis, and
P E Logue, and
R W Evans, and
J L Drucker
March 1990,
The Journal of the American Osteopathic Association,
F A Schmitt, and
J W Bigley, and
R McKinnis, and
P E Logue, and
R W Evans, and
J L Drucker
April 1991,
Nursing RSA = Verpleging RSA,
F A Schmitt, and
J W Bigley, and
R McKinnis, and
P E Logue, and
R W Evans, and
J L Drucker
December 1988,
Lancet (London, England),
F A Schmitt, and
J W Bigley, and
R McKinnis, and
P E Logue, and
R W Evans, and
J L Drucker
January 1991,
BMJ (Clinical research ed.),
F A Schmitt, and
J W Bigley, and
R McKinnis, and
P E Logue, and
R W Evans, and
J L Drucker
January 1989,
Journal of clinical laboratory analysis,
F A Schmitt, and
J W Bigley, and
R McKinnis, and
P E Logue, and
R W Evans, and
J L Drucker
November 1989,
Clinical pharmacology and therapeutics,
F A Schmitt, and
J W Bigley, and
R McKinnis, and
P E Logue, and
R W Evans, and
J L Drucker
January 1997,
Clinical pharmacology and therapeutics,
