According to Clark there are three different types of melanoma: malignant melanoma which develops from the floor of a precancerous melanosis, the extensive superficial melanoma and nodular malignant melanoma. Therapeutically, surgery occupies the first place. Chemotherapeutically the combination of 3 or 4 different substances has given favorable results. Immunotherapeutically, immunization with BCG and mycobacteria, especially Cornyebacterium parvum, is considered the most reliable and least dangerous procedure. Altogether, a better prognosis for malignant melanoma can be expected in the future if diagnosis is made early and if treated with an optimum combination therapy.