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The role of the renin-angiotensin system as a mediator of water intake, induced by hypovolemia after polyethylene glycol (PEG) injection, was investigated. Blockade of angiotensin I converting enzyme and of angiotensin receptors was used as a pharmacological tool. A significant reduction of water intake was observed when angiotensin I converting enzyme was inhibited by captopril and enalapril. In PEG-treated rats with blockade of angiotensin I converting enzyme, hypertonic saline injection continued to elicit substantial drinking. Normalization of low blood pressure by vasopressin infusions in PEG and captopril treated rats did not interfere with the antidipsogenic effectiveness of converting enzyme blockade. The angiotensin II receptor antagonist, saralasin, also reduced PEG-induced drinking although less effectively than converting enzyme inhibitors. We conclude that water intake due to isotonic depletion of the extracellular fluid compartment may depend on the activity of the renin-angiotensin system.
J F Mann, and
S Eisele, and
R Rettig, and
T Unger, and
A K Johnson, and
D Ganten, and
E Ritz
July 1979,
The American journal of physiology,
J F Mann, and
S Eisele, and
R Rettig, and
T Unger, and
A K Johnson, and
D Ganten, and
E Ritz
April 1983,
Experientia,
J F Mann, and
S Eisele, and
R Rettig, and
T Unger, and
A K Johnson, and
D Ganten, and
E Ritz
January 1979,
Eksperimentalna meditsina i morfologiia,
J F Mann, and
S Eisele, and
R Rettig, and
T Unger, and
A K Johnson, and
D Ganten, and
E Ritz
January 1986,
Acta physiologica et pharmacologica Bulgarica,
J F Mann, and
S Eisele, and
R Rettig, and
T Unger, and
A K Johnson, and
D Ganten, and
E Ritz
March 2003,
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
J F Mann, and
S Eisele, and
R Rettig, and
T Unger, and
A K Johnson, and
D Ganten, and
E Ritz
July 1972,
Medicina,
J F Mann, and
S Eisele, and
R Rettig, and
T Unger, and
A K Johnson, and
D Ganten, and
E Ritz
January 2010,
The journal of physiological sciences : JPS,
J F Mann, and
S Eisele, and
R Rettig, and
T Unger, and
A K Johnson, and
D Ganten, and
E Ritz
March 1976,
Pharmacology, biochemistry, and behavior,
J F Mann, and
S Eisele, and
R Rettig, and
T Unger, and
A K Johnson, and
D Ganten, and
E Ritz
September 1979,
Physiology & behavior,
J F Mann, and
S Eisele, and
R Rettig, and
T Unger, and
A K Johnson, and
D Ganten, and
E Ritz
January 1975,
Pharmacology, biochemistry, and behavior,
