-transparent.png){kind=logo}
Plasma renin activities (PRA) and aldosterone concentrations increased in parallel over a wide range of plasma volume deficits produced in unanesthetized rats by extravascular administration of polyethylene glycol (PEG) solution. When PEG-treated rats were given water to drink, their intakes were proportional to PRA; when given water and 0.5 M NaCl, PRA and the steroid concentrations diminished concurrently in association with sodium consumption. Aldosterone concentrations and NaCl intakes were markedly enhanced after PEG treatment in rats maintained on a sodium-deficient diet for 4 days. On the other hand, a clear relation between PRA and water intake, and between circulating aldosterone levels and sodium intake, was not suggested by other experiments in this series. For example, bilateral nephrectomy abolished the rise in PRA during hypovolemia yet rats drank water normally. Moreover, aldosterone concentrations were substantially elevated by PEG treatment in the nephrectomized rats yet sodium appetite was abolished. These and other findings suggest that neither angiotensin nor aldosterone plays a prominent role in stimulating water and saline intakes during hypovolemia.
E M Stricker, and
A H Vagnucci, and
R H McDonald, and
F H Leenen
October 1988,
Pflugers Archiv : European journal of physiology,
E M Stricker, and
A H Vagnucci, and
R H McDonald, and
F H Leenen
January 1985,
The American journal of physiology,
E M Stricker, and
A H Vagnucci, and
R H McDonald, and
F H Leenen
September 1970,
American journal of clinical pathology,
E M Stricker, and
A H Vagnucci, and
R H McDonald, and
F H Leenen
November 2003,
Physiology & behavior,
E M Stricker, and
A H Vagnucci, and
R H McDonald, and
F H Leenen
February 1983,
The American journal of physiology,
E M Stricker, and
A H Vagnucci, and
R H McDonald, and
F H Leenen
July 1983,
Cardiologia (Rome, Italy),
E M Stricker, and
A H Vagnucci, and
R H McDonald, and
F H Leenen
August 1982,
The Journal of laboratory and clinical medicine,
E M Stricker, and
A H Vagnucci, and
R H McDonald, and
F H Leenen
October 1996,
Physiology & behavior,
E M Stricker, and
A H Vagnucci, and
R H McDonald, and
F H Leenen
May 1989,
The American journal of physiology,
E M Stricker, and
A H Vagnucci, and
R H McDonald, and
F H Leenen
December 1955,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
