Biomaterial Database

Response of vertebral and carotid blood flow to isocapnic changes in end-tidal oxygen tension. 1986

J H Van Beek, and A Berkenbosch, and J De Goede, and C N Olievier

The response of the vertebral and carotid blood flow to isocapnic hypoxia was measured in 9 cats anaesthetized with chloralose-urethane using perivascular electromagnetic flow probes. The carotid flow was already significantly increased when going from hyperoxia (PETO2 55 kPa) to normoxia. For the vertebral blood flow a significant increase compared to hyperoxia was observed at a moderate level of hypoxia (PETO2 9 kPa). The time course of the response of the blood flow to isocapnic step-like changes in PETO2 was fitted with a first order model. The mean time constant (+/- SD) for steps into hypoxia for the carotid flow was 35 +/- 38 sec(8 cats) and for the vertebral flow, 44 +/- 37 sec (5 cats). The mean time constant (+/- SD) for steps out of hypoxia was significantly smaller and found to be 23 +/- 22 sec (8 cats) and 19 +/- 18 sec (4 cats), respectively. We argue that a major part of the changes in vertebral and carotid blood flow to steps into hypoxia goes to brain tissue.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D010313	Partial Pressure	The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Partial Pressures,Pressure, Partial,Pressures, Partial
D012039	Regional Blood Flow	The flow of BLOOD through or around an organ or region of the body.	Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002245	Carbon Dioxide	A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.	Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D002339	Carotid Arteries	Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.	Arteries, Carotid,Artery, Carotid,Carotid Artery
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D005260	Female		Females
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse