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Mammalian and teleost insulins increase active sodium transport by the toad urinary bladder at subnanomolar concentrations. This stimulation is evident within 15 min and persists for hours. Porcine proinsulin and a cross-linked derivative of bovine insulin are less effective than porcine insulin in stimulating the short-circuit current (SCC), indicating the specificity appropriate for activation of sodium transport through an insulin receptor. The initial stimulation by insulin of the SCC is not blocked by pretreatment with actinomycin D, puromycin, cycloheximide, or tunicamycin. However, in the presence of any one of these inhibitors the sustained increase in SCC is blocked and the rise is short-lived, lasting only 45 to 90 min. In amphotericin-treated bladders, the addition of insulin did not further stimulate SCC.
M H Cobb, and
C P Yang, and
J A Brown, and
W N Scott
January 1980,
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M H Cobb, and
C P Yang, and
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M H Cobb, and
C P Yang, and
J A Brown, and
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April 1977,
The Journal of membrane biology,
M H Cobb, and
C P Yang, and
J A Brown, and
W N Scott
March 1977,
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M H Cobb, and
C P Yang, and
J A Brown, and
W N Scott
October 1971,
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M H Cobb, and
C P Yang, and
J A Brown, and
W N Scott
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M H Cobb, and
C P Yang, and
J A Brown, and
W N Scott
August 1986,
The Journal of pharmacology and experimental therapeutics,
M H Cobb, and
C P Yang, and
J A Brown, and
W N Scott
January 1975,
The Journal of membrane biology,
M H Cobb, and
C P Yang, and
J A Brown, and
W N Scott
March 1978,
The American journal of physiology,
M H Cobb, and
C P Yang, and
J A Brown, and
W N Scott
October 1965,
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