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Production of interferon (IFN)-gamma by peripheral blood leukocytes (PBL) was examined in cultures of unseparated fresh whole blood exposed to phytohemagglutinin (PHA), concanavalin A (Con A), or pokeweed mitogen (PWM). The yield of IFN-gamma was measured by a newly developed immunoradiometric assay. Nine of 14 patients with acute pulmonary tuberculosis (TB) showed a depressed IFN-gamma response to Con A and/or PWM. Only four of these TB patients also showed a depressed IFN-gamma response to PHA. Stimulation of the patients' PBL cultures with PHA in the presence of exogenous interleukin 2 (IL 2) produced normal IFN-gamma yields in all but the most severely depressed patients. PBL cultures of TB patients with defective IFN-gamma production in response to mitogenic lectins also produced less IFN-gamma after stimulation with tuberculin PPD. Although some patients showed a moderate degree of lymphopenia, their OKT4/T8 lymphocyte ratios were mostly normal or close to normal, with the notable exception of one TB patient who has been diagnosed to have the acquired immune deficiency syndrome (AIDS).
J Vilcek, and
A Klion, and
D Henriksen-DeStefano, and
A Zemtsov, and
D M Davidson, and
M Davidson, and
A E Friedman-Kien, and
J Le
January 1996,
Archivum immunologiae et therapiae experimentalis,
J Vilcek, and
A Klion, and
D Henriksen-DeStefano, and
A Zemtsov, and
D M Davidson, and
M Davidson, and
A E Friedman-Kien, and
J Le
April 1992,
Chest,
J Vilcek, and
A Klion, and
D Henriksen-DeStefano, and
A Zemtsov, and
D M Davidson, and
M Davidson, and
A E Friedman-Kien, and
J Le
June 1985,
Journal of medical virology,
J Vilcek, and
A Klion, and
D Henriksen-DeStefano, and
A Zemtsov, and
D M Davidson, and
M Davidson, and
A E Friedman-Kien, and
J Le
February 1996,
European journal of clinical investigation,
J Vilcek, and
A Klion, and
D Henriksen-DeStefano, and
A Zemtsov, and
D M Davidson, and
M Davidson, and
A E Friedman-Kien, and
J Le
September 2008,
The Netherlands journal of medicine,
J Vilcek, and
A Klion, and
D Henriksen-DeStefano, and
A Zemtsov, and
D M Davidson, and
M Davidson, and
A E Friedman-Kien, and
J Le
March 1984,
Nagoya journal of medical science,
J Vilcek, and
A Klion, and
D Henriksen-DeStefano, and
A Zemtsov, and
D M Davidson, and
M Davidson, and
A E Friedman-Kien, and
J Le
August 1988,
Journal of interferon research,
J Vilcek, and
A Klion, and
D Henriksen-DeStefano, and
A Zemtsov, and
D M Davidson, and
M Davidson, and
A E Friedman-Kien, and
J Le
May 1992,
Journal of interferon research,
J Vilcek, and
A Klion, and
D Henriksen-DeStefano, and
A Zemtsov, and
D M Davidson, and
M Davidson, and
A E Friedman-Kien, and
J Le
April 1996,
Scandinavian journal of clinical and laboratory investigation,
J Vilcek, and
A Klion, and
D Henriksen-DeStefano, and
A Zemtsov, and
D M Davidson, and
M Davidson, and
A E Friedman-Kien, and
J Le
August 1998,
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology,
