Interferon production by peripheral blood leukocytes of patients with acute myeloid leukemia. 1996

M Kandefer-Szerszeń, and A Dmoszyńska, and L Borowska, and M Adamczyk-Cioch, and M Hus, and I Hus, and J Roliński
Department of Virology and Immunology, Maria Curie-Sklodowska University, Lublin, Poland.

The ability of peripheral blood leukocytes (PBL) of 13 selected patients with acute myeloid leukemia (AML), and of 10 healthy subjects to produce interferon (IFN) spontaneously and after in vitro induction was tested. Spontaneous IFN production was detected in supernatants of PBL cultures of healthy subjects but was not present in cultures of leukemic cells (leukocytes density 1 x 10(6) ml). After induction with Newcastle disease virus (NDV) PBL cultures from 5 patients with AML exhibited a low IFN response, while in others IFN titers were similar to controls. The IFN titers induced with lipopolysaccharide (LPS) were lower in leukemic cells than those detected in control cells. The absence or low IFN levels after induction with phytohemagglutinin (PHA) correlated with very small numbers of normal lymphocytes in blood of leukemic patients.

UI MeSH Term Description Entries
D007372 Interferons Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions. Interferon
D007948 Leukemia, Monocytic, Acute An acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes, and MONOCYTES. Leukemia, Monoblastic, Acute,Leukemia, Myeloid, Acute, M5,Leukemia, Myeloid, Schilling-Type,Monoblastic Leukemia, Acute,Monocytic Leukemia, Acute,Myeloid Leukemia, Acute, M5,Myeloid Leukemia, Schilling-Type,Leukemia, Acute Monocytic,Leukemia, Myeloid, Schilling Type,Acute Monoblastic Leukemia,Acute Monoblastic Leukemias,Acute Monocytic Leukemia,Acute Monocytic Leukemias,Leukemia, Schilling-Type Myeloid,Leukemias, Acute Monoblastic,Leukemias, Acute Monocytic,Monoblastic Leukemias, Acute,Monocytic Leukemias, Acute,Myeloid Leukemia, Schilling Type,Schilling-Type Myeloid Leukemia
D007963 Leukocytes, Mononuclear Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules. Mononuclear Leukocyte,Mononuclear Leukocytes,PBMC Peripheral Blood Mononuclear Cells,Peripheral Blood Human Mononuclear Cells,Peripheral Blood Mononuclear Cell,Peripheral Blood Mononuclear Cells,Leukocyte, Mononuclear
D008297 Male Males
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D014407 Tumor Cells, Cultured Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. Cultured Tumor Cells,Neoplastic Cells, Cultured,Cultured Neoplastic Cells,Cell, Cultured Neoplastic,Cell, Cultured Tumor,Cells, Cultured Neoplastic,Cells, Cultured Tumor,Cultured Neoplastic Cell,Cultured Tumor Cell,Neoplastic Cell, Cultured,Tumor Cell, Cultured

Related Publications

M Kandefer-Szerszeń, and A Dmoszyńska, and L Borowska, and M Adamczyk-Cioch, and M Hus, and I Hus, and J Roliński
March 1986, Journal of clinical immunology,
M Kandefer-Szerszeń, and A Dmoszyńska, and L Borowska, and M Adamczyk-Cioch, and M Hus, and I Hus, and J Roliński
September 2019, Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology,
M Kandefer-Szerszeń, and A Dmoszyńska, and L Borowska, and M Adamczyk-Cioch, and M Hus, and I Hus, and J Roliński
March 1995, Experimental hematology,
M Kandefer-Szerszeń, and A Dmoszyńska, and L Borowska, and M Adamczyk-Cioch, and M Hus, and I Hus, and J Roliński
January 1996, Archivum immunologiae et therapiae experimentalis,
M Kandefer-Szerszeń, and A Dmoszyńska, and L Borowska, and M Adamczyk-Cioch, and M Hus, and I Hus, and J Roliński
January 1996, Archivum immunologiae et therapiae experimentalis,
M Kandefer-Szerszeń, and A Dmoszyńska, and L Borowska, and M Adamczyk-Cioch, and M Hus, and I Hus, and J Roliński
January 1989, Archivum immunologiae et therapiae experimentalis,
M Kandefer-Szerszeń, and A Dmoszyńska, and L Borowska, and M Adamczyk-Cioch, and M Hus, and I Hus, and J Roliński
April 1992, Chest,
M Kandefer-Szerszeń, and A Dmoszyńska, and L Borowska, and M Adamczyk-Cioch, and M Hus, and I Hus, and J Roliński
August 1977, Cellular immunology,
M Kandefer-Szerszeń, and A Dmoszyńska, and L Borowska, and M Adamczyk-Cioch, and M Hus, and I Hus, and J Roliński
June 1985, Journal of medical virology,
M Kandefer-Szerszeń, and A Dmoszyńska, and L Borowska, and M Adamczyk-Cioch, and M Hus, and I Hus, and J Roliński
August 1988, Journal of interferon research,
Copied contents to your clipboard!