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Infectivity of human T-cell lymphotropic virus, Type III (HTLV-III) was inactivated by heat more rapidly if in liquid medium than if lyophilized and more rapidly at 60 degrees than 56 degrees C. When HTLV-III was added to factor VIII suspension, then lyophilized and heated at 60 degrees C for 2 hours or longer there was elimination of 1 X 10(6) in vitro infectious units (IVIU) of virus. Much of the viral inactivation appeared to result from lyophilization. The application of water-saturated chloroform to the lyophilized material containing virus also resulted in elimination of infectivity. HTLV-III was efficiently inactivated by formalin, beta-propiolactone, ethyl ether, detergent, and ultraviolet light plus psoralen. The results are reassuring regarding the potential safety of various biological products.
G V Quinnan, and
M A Wells, and
A E Wittek, and
M A Phelan, and
R E Mayner, and
S Feinstone, and
R H Purcell, and
J S Epstein
June 1986,
Journal of clinical microbiology,
G V Quinnan, and
M A Wells, and
A E Wittek, and
M A Phelan, and
R E Mayner, and
S Feinstone, and
R H Purcell, and
J S Epstein
April 1987,
Applied and environmental microbiology,
G V Quinnan, and
M A Wells, and
A E Wittek, and
M A Phelan, and
R E Mayner, and
S Feinstone, and
R H Purcell, and
J S Epstein
August 1985,
The Journal of infectious diseases,
G V Quinnan, and
M A Wells, and
A E Wittek, and
M A Phelan, and
R E Mayner, and
S Feinstone, and
R H Purcell, and
J S Epstein
January 1987,
Hematologic pathology,
G V Quinnan, and
M A Wells, and
A E Wittek, and
M A Phelan, and
R E Mayner, and
S Feinstone, and
R H Purcell, and
J S Epstein
June 1985,
Lancet (London, England),
G V Quinnan, and
M A Wells, and
A E Wittek, and
M A Phelan, and
R E Mayner, and
S Feinstone, and
R H Purcell, and
J S Epstein
September 1985,
Lancet (London, England),
G V Quinnan, and
M A Wells, and
A E Wittek, and
M A Phelan, and
R E Mayner, and
S Feinstone, and
R H Purcell, and
J S Epstein
December 1985,
Annals of internal medicine,
G V Quinnan, and
M A Wells, and
A E Wittek, and
M A Phelan, and
R E Mayner, and
S Feinstone, and
R H Purcell, and
J S Epstein
November 1985,
The New England journal of medicine,
G V Quinnan, and
M A Wells, and
A E Wittek, and
M A Phelan, and
R E Mayner, and
S Feinstone, and
R H Purcell, and
J S Epstein
January 1986,
Histology and histopathology,
G V Quinnan, and
M A Wells, and
A E Wittek, and
M A Phelan, and
R E Mayner, and
S Feinstone, and
R H Purcell, and
J S Epstein
May 1986,
The Journal of clinical investigation,
