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One-hundred thirteen adults and children with hemophilia or other congenital bleeding disorders were vaccinated against the hepatitis B virus. Each patient was given three subcutaneous injections of the vaccine at monthly intervals and then a fourth booster dose 14 months after the first. The vaccine was highly immunogenic, since 111 of 113 patients (98%) produced anti-HBs (10 mIU/ml or more). After the first three vaccine doses and after the booster dose, ten anti-LAV/HTLV-III-positive hemophiliacs produced anti-HBs but had a lower average titer than anti-LAV/HTLV-III-negative hemophiliacs. Of the 23 patients treated with concentrates in the 15 month postvaccination period only, none acquired HBV infection. Of the 50 patients treated with concentrates also in the 6 month prevaccination period, one developed hepatitis B. In summary, the vaccine was highly immunogenic in both children and adults with hemophilia; anti-LAV/HTLV-III-positive patients responded to the vaccine, but the average anti-HBs response was lower; no case of hepatitis B occurred in patients treated with concentrates only in the postvaccination period.
A R Zanetti, and
P M Mannucci, and
E Tanzi, and
G A Moroni, and
M De Paschale, and
M Morfini, and
V Carnelli, and
M C Tirindelli, and
R De Biasi, and
N Ciavarella
March 1986,
Ugeskrift for laeger,
A R Zanetti, and
P M Mannucci, and
E Tanzi, and
G A Moroni, and
M De Paschale, and
M Morfini, and
V Carnelli, and
M C Tirindelli, and
R De Biasi, and
N Ciavarella
January 1986,
The New England journal of medicine,
A R Zanetti, and
P M Mannucci, and
E Tanzi, and
G A Moroni, and
M De Paschale, and
M Morfini, and
V Carnelli, and
M C Tirindelli, and
R De Biasi, and
N Ciavarella
June 1986,
JAMA,
A R Zanetti, and
P M Mannucci, and
E Tanzi, and
G A Moroni, and
M De Paschale, and
M Morfini, and
V Carnelli, and
M C Tirindelli, and
R De Biasi, and
N Ciavarella
December 1986,
AIDS research,
A R Zanetti, and
P M Mannucci, and
E Tanzi, and
G A Moroni, and
M De Paschale, and
M Morfini, and
V Carnelli, and
M C Tirindelli, and
R De Biasi, and
N Ciavarella
January 1986,
AIDS research,
A R Zanetti, and
P M Mannucci, and
E Tanzi, and
G A Moroni, and
M De Paschale, and
M Morfini, and
V Carnelli, and
M C Tirindelli, and
R De Biasi, and
N Ciavarella
April 1986,
Medicina clinica,
A R Zanetti, and
P M Mannucci, and
E Tanzi, and
G A Moroni, and
M De Paschale, and
M Morfini, and
V Carnelli, and
M C Tirindelli, and
R De Biasi, and
N Ciavarella
November 1986,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
A R Zanetti, and
P M Mannucci, and
E Tanzi, and
G A Moroni, and
M De Paschale, and
M Morfini, and
V Carnelli, and
M C Tirindelli, and
R De Biasi, and
N Ciavarella
February 1987,
Journal of immunology (Baltimore, Md. : 1950),
A R Zanetti, and
P M Mannucci, and
E Tanzi, and
G A Moroni, and
M De Paschale, and
M Morfini, and
V Carnelli, and
M C Tirindelli, and
R De Biasi, and
N Ciavarella
May 1987,
Blood,
A R Zanetti, and
P M Mannucci, and
E Tanzi, and
G A Moroni, and
M De Paschale, and
M Morfini, and
V Carnelli, and
M C Tirindelli, and
R De Biasi, and
N Ciavarella
April 1986,
British dental journal,
