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Peripheral blood lymphocyte subsets and the incidence of LAV/HTLV-III antibodies were studied in 63 patients with hemophilia A who had been transfused with a low dose regimen of commercial (U.S.A.) factor VIII concentrates. Five patients with hemophilia B were also included in this study. In hemophilia A patients a significant reduction in the percentage and absolute numbers of T4+ cells and of the T4/T8 ratio and a significant increase in the percentage of T8+ and Leu-7+ cells were observed. These abnormalities were independent of the presence of anti-LAV/HTLV-III. In hemophilia B patients a significant increase of T8+ cells and a decrease of T4/T8 ratio was noted while the percentage of Leu-7+ cells was normal. A significant negative correlation of F VIII units transfused and T4/T8 ratio was seen only in LAV/HTLV (-) patients, suggesting that F VIII per se could cause immunodysregulation. Seropositive patients were found to have consumed a larger amount of F VIII units than seronegative patients during the period 1980-1984 (p less than 0.005).
H Choremi, and
J Economidou, and
K Psarra, and
E Sidiri, and
T Mandalaki, and
C Louizou, and
A Gialeraki, and
C Markakis, and
C Papaevangelou, and
G Kallinicos
June 1986,
JAMA,
H Choremi, and
J Economidou, and
K Psarra, and
E Sidiri, and
T Mandalaki, and
C Louizou, and
A Gialeraki, and
C Markakis, and
C Papaevangelou, and
G Kallinicos
April 1986,
Medicina clinica,
H Choremi, and
J Economidou, and
K Psarra, and
E Sidiri, and
T Mandalaki, and
C Louizou, and
A Gialeraki, and
C Markakis, and
C Papaevangelou, and
G Kallinicos
February 1987,
Blut,
H Choremi, and
J Economidou, and
K Psarra, and
E Sidiri, and
T Mandalaki, and
C Louizou, and
A Gialeraki, and
C Markakis, and
C Papaevangelou, and
G Kallinicos
January 1986,
The New England journal of medicine,
H Choremi, and
J Economidou, and
K Psarra, and
E Sidiri, and
T Mandalaki, and
C Louizou, and
A Gialeraki, and
C Markakis, and
C Papaevangelou, and
G Kallinicos
December 1986,
American journal of hematology,
H Choremi, and
J Economidou, and
K Psarra, and
E Sidiri, and
T Mandalaki, and
C Louizou, and
A Gialeraki, and
C Markakis, and
C Papaevangelou, and
G Kallinicos
June 1985,
Blood,
H Choremi, and
J Economidou, and
K Psarra, and
E Sidiri, and
T Mandalaki, and
C Louizou, and
A Gialeraki, and
C Markakis, and
C Papaevangelou, and
G Kallinicos
February 1987,
Clinical chemistry,
H Choremi, and
J Economidou, and
K Psarra, and
E Sidiri, and
T Mandalaki, and
C Louizou, and
A Gialeraki, and
C Markakis, and
C Papaevangelou, and
G Kallinicos
December 1985,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
H Choremi, and
J Economidou, and
K Psarra, and
E Sidiri, and
T Mandalaki, and
C Louizou, and
A Gialeraki, and
C Markakis, and
C Papaevangelou, and
G Kallinicos
January 1986,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
H Choremi, and
J Economidou, and
K Psarra, and
E Sidiri, and
T Mandalaki, and
C Louizou, and
A Gialeraki, and
C Markakis, and
C Papaevangelou, and
G Kallinicos
December 1986,
AIDS research,
