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Expression from the Drosophila melanogaster hsp70 promoter was controlled by a regulatory unit that was composed of two sequence elements that resembled the heat shock consensus sequence. The unit functioned in both orientations and at different distances from downstream promoter sequences. Each element of the unit alone was essentially inactive. Association of two elements resulted in a dramatic increase of transcription from the hsp70 promoter. This synergistic effect was independent of the relative orientation of the elements and, to a large extent, of the distance between them. Duplication of a region containing only one element also yielded a highly active, heat-regulated promoter. Genes with three to five elements were three to four times more active than those with a single regulatory unit.
J Amin, and
R Mestril, and
P Schiller, and
M Dreano, and
R Voellmy
October 2002,
Cell stress & chaperones,
J Amin, and
R Mestril, and
P Schiller, and
M Dreano, and
R Voellmy
February 1984,
Journal of molecular biology,
J Amin, and
R Mestril, and
P Schiller, and
M Dreano, and
R Voellmy
April 1989,
Molecular and cellular biology,
J Amin, and
R Mestril, and
P Schiller, and
M Dreano, and
R Voellmy
November 1991,
The New biologist,
J Amin, and
R Mestril, and
P Schiller, and
M Dreano, and
R Voellmy
July 1999,
The American naturalist,
J Amin, and
R Mestril, and
P Schiller, and
M Dreano, and
R Voellmy
January 1986,
The Journal of biological chemistry,
J Amin, and
R Mestril, and
P Schiller, and
M Dreano, and
R Voellmy
January 2016,
Cell stress & chaperones,
J Amin, and
R Mestril, and
P Schiller, and
M Dreano, and
R Voellmy
May 2003,
Molecular ecology,
J Amin, and
R Mestril, and
P Schiller, and
M Dreano, and
R Voellmy
November 1999,
Oecologia,
J Amin, and
R Mestril, and
P Schiller, and
M Dreano, and
R Voellmy
October 1981,
Nucleic acids research,
