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We have studied the effects of short-term treatment with lithium carbonate (900-1,200 mg/day for 4 days) on insulin secretion and blood glucose levels of 28 healthy volunteers (8 females and 20 males, aged 23-29 years) who underwent the following stimulations: two intravenous glucose loads of 25 and 5 g (IVGTT25; IVGTT5); arginine infusion (25 g over 30 min); tolbutamide test (0.25 g i.v.). Seven subjects for each group were tested. A placebo treatment was also performed. Short-term lithium treatment significantly reduced the insulin response to IVGTT25, arginine and tolbutamide. No differences were observed in blood glucose levels during all stimuli. Serum electrolyte levels and thyroid function were not affected by the treatment. In conclusion, these findings suggest, in healthy subjects, a good peripheral glucose utilization after brief-term lithium administration, in spite of impaired insulin response to various stimuli.
F Caviezel, and
A G Cattaneo, and
G Cetta, and
G Pozza
June 1986,
The American journal of physiology,
F Caviezel, and
A G Cattaneo, and
G Cetta, and
G Pozza
October 1978,
Archives internationales de pharmacodynamie et de therapie,
F Caviezel, and
A G Cattaneo, and
G Cetta, and
G Pozza
January 1986,
Endocrinologie,
F Caviezel, and
A G Cattaneo, and
G Cetta, and
G Pozza
November 1971,
Clinical science,
F Caviezel, and
A G Cattaneo, and
G Cetta, and
G Pozza
January 1974,
Pharmacology, biochemistry, and behavior,
F Caviezel, and
A G Cattaneo, and
G Cetta, and
G Pozza
March 1988,
Drug intelligence & clinical pharmacy,
F Caviezel, and
A G Cattaneo, and
G Cetta, and
G Pozza
July 1979,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
F Caviezel, and
A G Cattaneo, and
G Cetta, and
G Pozza
August 1975,
Diabetes,
F Caviezel, and
A G Cattaneo, and
G Cetta, and
G Pozza
May 1974,
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
F Caviezel, and
A G Cattaneo, and
G Cetta, and
G Pozza
January 1988,
Diabete & metabolisme,
