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Nine normal and two mildly hypertriglyceridemic subjects were treated with 2 g of clofibrate per day for 8 days. A significant fall in serum triglyceride and cholesterol concentration was observed from the second day onwards whereas free fatty acid levels were minimally affected. Insulin and glucagon responses to the ingestion of 200 g of meat were tested before and at the end of clofibrate treatment. Insulin response was significantly depressed (-28 +/- 12%) by the drug whereas glucagon response was enhanced but not to a significant degree. The ratio between insulin response and glucagon response was decreased by 38 +/- 11% (p less than 0.01) after treatment. A positive correlation was observed between the effects of clofibrate on basal triglyceride concentration on one hand and the effects of the drug on insulin and insulin/glucagon response to the protein meal on the other hand. Since insulin and glucagon are known to influence triglyceride metabolism, our data are compatible with the concept that the hypotriglyceridemic effect of clofibrate is--at least partly--related to the observed changes in insulin and glucagon reactivity.
F Fery, and
E O Balasse
May 1974,
Metabolism: clinical and experimental,
F Fery, and
E O Balasse
April 1987,
International journal of clinical pharmacology, therapy, and toxicology,
F Fery, and
E O Balasse
May 1977,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
F Fery, and
E O Balasse
November 1972,
Metabolism: clinical and experimental,
F Fery, and
E O Balasse
January 1973,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
F Fery, and
E O Balasse
April 1976,
Archives of disease in childhood,
F Fery, and
E O Balasse
February 1986,
Clinical nutrition (Edinburgh, Scotland),
F Fery, and
E O Balasse
December 1977,
Diabetologia,
F Fery, and
E O Balasse
September 1966,
The Journal of clinical investigation,
F Fery, and
E O Balasse
November 1975,
The Journal of clinical endocrinology and metabolism,
