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The effects of an opioid antagonist, naloxone, on the secretion of gonadotrophins were investigated in the long term ovariectomized rabbit. In the intact and acutely ovariectomized rabbit (2 days p.o.) naloxone at 10 mg/kg induced an increase of 260-300% in LH secretion at 40 min post-injection. From days 33-66 post-surgery naloxone at 10 mg/kg caused significant elevations in LH release even when animals were treated with estradiol benzoate 24 h previously. By contrast, treatment with oestradiol benzoate 3 h before naloxone abolished the LH increase. An LH surge could be elicited in these rabbits with GnRH treatment. These studies indicated that long term ovariectomy in the female rabbit does not completely remove the opioid control of GnRH release and that the LH response to naloxone is influenced by circulating estradiol levels.
E V YoungLai, and
M Wilkinson, and
N Thompson
January 1975,
Hormone research,
E V YoungLai, and
M Wilkinson, and
N Thompson
May 1956,
Annales d'endocrinologie,
E V YoungLai, and
M Wilkinson, and
N Thompson
October 1990,
Journal of animal science,
E V YoungLai, and
M Wilkinson, and
N Thompson
April 2007,
Journal of applied physiology (Bethesda, Md. : 1985),
E V YoungLai, and
M Wilkinson, and
N Thompson
August 1973,
Journal of animal science,
E V YoungLai, and
M Wilkinson, and
N Thompson
January 2006,
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society,
E V YoungLai, and
M Wilkinson, and
N Thompson
May 1993,
Theriogenology,
E V YoungLai, and
M Wilkinson, and
N Thompson
November 2002,
Metabolism: clinical and experimental,
E V YoungLai, and
M Wilkinson, and
N Thompson
August 1986,
The Journal of endocrinology,
E V YoungLai, and
M Wilkinson, and
N Thompson
March 1975,
Endocrinology,
