Effect of α2-adrenoceptor antagonism on the minimum alveolar concentration of isoflurane in cats. 2019

Bruno H Pypendop, and Hanna Ahokoivu, and Juhana Honkavaara
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA. Electronic address: bhpypendop@ucdavis.edu.

OBJECTIVE To characterize the effect of α2-adrenoceptor antagonism on the minimum alveolar concentration of isoflurane (MACISO) in cats. METHODS Prospective experimental study. METHODS A group of five healthy adult male neutered cats. METHODS Cats were anesthetized with isoflurane in oxygen and instrumented. MACISO was determined in duplicate in five cats, before and during administration of atipamezole (250 μg kg-1 followed by 250 μg kg-1 hour-1) using the bracketing technique and tail clamping. Estimates of MACISO obtained before and during administration of atipamezole were compared using a two-tailed paired t test. RESULTS MACISO during atipamezole administration (mean ± standard deviation 2.73% ± 0.07%) was significantly larger than before atipamezole administration (1.95% ± 0.13%; p < 0.0001). CONCLUSIONS The role of α2-adrenoceptors in inhaled anesthetic-induced immobility may be larger than previously thought. Antagonism of an α2-adrenoceptor agonist during inhalation anesthesia may result in an increase in MAC disproportionate to the MAC reduction induced by the agonist.

UI MeSH Term Description Entries
D007093 Imidazoles Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
D007530 Isoflurane A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
D008297 Male Males
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D011650 Pulmonary Alveoli Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place. Alveoli, Pulmonary,Alveolus, Pulmonary,Pulmonary Alveolus
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D000769 Anesthesia, Inhalation Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract. Insufflation Anesthesia,Anesthesia, Insufflation,Inhalation Anesthesia
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D058669 Adrenergic alpha-2 Receptor Antagonists Drugs that bind to and block the activation of ADRENERGIC ALPHA-2 RECEPTORS. Adrenergic alpha-2 Antagonists,Adrenergic alpha-2 Receptor Blockers,Adrenergic alpha2-Antagonists,alpha-2 Adrenergic Blocking Agents,alpha2-Adrenergic Antagonists,Adrenergic alpha 2 Antagonists,Adrenergic alpha 2 Receptor Antagonists,Adrenergic alpha 2 Receptor Blockers,Adrenergic alpha2 Antagonists,Antagonists, Adrenergic alpha-2,Antagonists, alpha2-Adrenergic,alpha 2 Adrenergic Blocking Agents,alpha-2 Antagonists, Adrenergic,alpha2 Adrenergic Antagonists,alpha2-Antagonists, Adrenergic
D018685 Anesthetics, Inhalation Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173) Inhalation Anesthetic,Inhalation Anesthetics,Anesthetic Gases,Anesthetic, Inhalation,Gases, Anesthetic

Related Publications

Bruno H Pypendop, and Hanna Ahokoivu, and Juhana Honkavaara
November 1997, American journal of veterinary research,
Bruno H Pypendop, and Hanna Ahokoivu, and Juhana Honkavaara
April 2012, Journal of veterinary pharmacology and therapeutics,
Bruno H Pypendop, and Hanna Ahokoivu, and Juhana Honkavaara
April 2024, Veterinary anaesthesia and analgesia,
Bruno H Pypendop, and Hanna Ahokoivu, and Juhana Honkavaara
October 2001, Veterinary anaesthesia and analgesia,
Bruno H Pypendop, and Hanna Ahokoivu, and Juhana Honkavaara
November 2020, Journal of veterinary pharmacology and therapeutics,
Bruno H Pypendop, and Hanna Ahokoivu, and Juhana Honkavaara
July 2004, Veterinary anaesthesia and analgesia,
Bruno H Pypendop, and Hanna Ahokoivu, and Juhana Honkavaara
March 2022, Veterinary anaesthesia and analgesia,
Bruno H Pypendop, and Hanna Ahokoivu, and Juhana Honkavaara
January 2023, Frontiers in veterinary science,
Bruno H Pypendop, and Hanna Ahokoivu, and Juhana Honkavaara
January 2007, Veterinary anaesthesia and analgesia,
Bruno H Pypendop, and Hanna Ahokoivu, and Juhana Honkavaara
June 2003, Journal of the American Veterinary Medical Association,
Copied contents to your clipboard!