Biomaterial Database

Equations for the calculation of factor VIII potencies from the results of parallel-line clotting-time assays. 1988

S S Kuwahara

Biochemistry and Bioassay Section, Michigan Department of Public Health, Lansing 48909.

An equation was derived: 1nC01 = 1nD1 - (a2/a1)1nD2 + (a2/a1) 1nC02 + 1/a1(b1-b2) which related the potency of a sample (C01) to the potency of a standard (C02) via the dilution factors (D1 & D2) that produced common clotting times for the sample and standard. This equation could not be used in practice since C01 and b1 were both unknown. Derivation of a usable formula for calculating sample potencies was found to require the assumption that b1 = b2. It was found that b is not always a constant in Factor VIII assays and may vary with the nature of the clotting assay mixtures.

UI	MeSH Term	Description	Entries
D012016	Reference Values	The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.	Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D001780	Blood Coagulation Tests	Laboratory tests for evaluating the individual's clotting mechanism.	Coagulation Tests, Blood,Tests, Blood Coagulation,Blood Coagulation Test,Coagulation Test, Blood,Test, Blood Coagulation
D005169	Factor VIII	Factor VIII of blood coagulation. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.	Coagulation Factor VIII,Factor VIII Clotting Antigen,Factor VIII Coagulant Antigen,Factor VIII Procoagulant Activity,Thromboplastinogen,Blood Coagulation Factor VIII,F VIII-C,Factor 8,Factor 8 C,Factor Eight,Factor VIIIC,Hyate-C,Hyatt-C,F VIII C,Hyate C,HyateC,Hyatt C,HyattC
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014914	Whole Blood Coagulation Time	The time required by whole blood to produce a visible clot.	Activated Coagulation Time, Whole Blood,Blood Coagulation Time, Whole,Coagulation Time, Whole Blood